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Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M 由 Kenneth S. Thress, Cloud P. Paweletz, Enriqueta Felip, Byoung Chul Cho, Daniel Stetson, Brian Dougherty, Zhongwu Lai, Aleksandra Markovets, Ana Vivancos, Yanan Kuang, Dalia Ercan, Sarah E Matthews, Mireille Cantarini, J. Carl Barrett, Pasi A. Jänne, Geoffrey R. Oxnard

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Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma 由 Valentina Pirazzoli, Deborah Ayeni, Catherine B. Meador, Basavaraju G. Sanganahalli, Fahmeed Hyder, Elisa de Stanchina, Sarah B. Goldberg, William Pao, Katerina Politi

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<i>In vitro</i> modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant <i>EGFR</i> mutants in non-small-cell lung cancer 由 Toshiyuki Hirano, Hiroyuki Yasuda, Tetsuo Tani, Junko Hamamoto, Ayano Oashi, Kota Ishioka, Daisuke Arai, Shigenari Nukaga, Masayoshi Miyawaki, Ichiro Kawada, Katsuhiko Naoki, Daniel B. Costa, Susumu Kobayashi, Tomoko Betsuyaku, Kenzo Soejima

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EGFR-independent mechanisms of acquired resistance to AZD9291 in EGFR T790M-positive NSCLC patients 由 David Planchard, Yohann Loriot, Fabrice André, A. Gobert, Nathalie Auger, Ludovic Lacroix, Jean‐Charles Soria

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Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors 由 Mizuki Nishino, Stephanie Cardarella, Suzanne E. Dahlberg, David M. Jackman, Nikhil H. Ramaiya, Hiroto Hatabu, Michael S. Rabin, Pasi A. Jnne, Bruce E. Johnson

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Molecular mechanisms of resistance in epidermal growth factor receptor-mutant lung adenocarcinomas 由 Alexis B. Cortot, Pasi A. Jänne

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Acquired Resistance of EGFR-Mutant Lung Adenocarcinomas to Afatinib plus Cetuximab Is Associated with Activation of mTORC1 由 Valentina Pirazzoli, Caroline A. Nebhan, Xiaoling Song, Anna Wurtz, Zenta Walther, Guoping Cai, Zhongming Zhao, Peilin Jia, Elisa de Stanchina, Erik M. Shapiro, Molly Gale, Ruonan Yin, Leora Horn, David P. Carbone, Philip J. Stephens, Vincent A. Miller, Scott Gettinger, William Pao, Katerina Politi

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Screening for Germline EGFR T790M Mutations Through Lung Cancer Genotyping 由 Geoffrey R. Oxnard, Vincent A. Miller, Mark E. Robson, Christopher G. Azzoli, William Pao, Marc Ladanyi, Maria E. Arcila

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Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer 由 Lucía Regales, Yixuan Gong, Ronglai Shen, Elisa de Stanchina, Igor Vivanco, Aviva Goel, Jason A. Koutcher, Maria Spassova, Ouathek Ouerfelli, Ingo K. Mellinghoff, Maureen F. Zakowski, Katerina Politi, William Pao

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Combined EGFR/MET or EGFR/HSP90 Inhibition Is Effective in the Treatment of Lung Cancers Codriven by Mutant EGFR Containing T790M and MET 由 Lu Xu, Eiki Kikuchi, Chunxiao Xu, Hiromichi Ebi, Dalia Ercan, Katherine A. Cheng, Robert F. Padera, Jeffrey A. Engelman, Pasi A. Jänne, Geoffrey I. Shapiro, Takeshi Shimamura, Kwok‐Kin Wong

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Targeting epidermal growth factor receptor: Central signaling kinase in lung cancer 由 Takeshi Yoshida, Guolin Zhang, Eric B. Haura

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Afatinib: emerging next-generation tyrosine kinase inhibitor for NSCLC 由 Mark Agulnik, Nelson, Ziehr, J R Johnson

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<i>MET</i> amplification occurs with or without <i>T790M</i> mutations in <i>EGFR</i> mutant lung tumors with acquired resistance to gefitinib or erlotinib 由 James Bean, Cameron Brennan, Jin‐Yuan Shih, Gregory J. Riely, Agnès Viale, Lu Wang, Dhananjay Chitale, Noriko Motoi, János Szőke, Stephen Broderick, Marissa N. Balak, W.C. Chang, Chong‐Jen Yu, Adi F. Gazdar, Harvey I. Pass, Valerie W. Rusch, William L. Gerald, Shiu‐Feng Huang, Pan‐Chyr Yang, Vincent A. Miller, Marc Ladanyi, James Chih‐Hsin Yang, William Pao

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Double <i>EGFR</i> mutants containing rare <i>EGFR</i> mutant types show reduced <i>in vitro</i> response to gefitinib compared with common activating missense mutations 由 Issan Yee San Tam, Elaine Lai‐Han Leung, Vicky Pui‐Chi Tin, Daniel Chua, Alan Dart‐Loon Sihoe, Lik‐Cheung Cheng, Lap-Ping Chung, Maria P. Wong

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Activation of IL-6R/JAK1/STAT3 Signaling Induces <i>De Novo</i> Resistance to Irreversible EGFR Inhibitors in Non–Small Cell Lung Cancer with T790M Resistance Mutation 由 Sun Mi Kim, Oh-Joon Kwon, Yun Hong, Joo Hang Kim, Flavio Solca, Sang‐Jun Ha, Ross A. Soo, James G. Christensen, Ji Hyun Lee, Byoung Chul Cho

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The<i>EGFR</i>T790M Mutation in Acquired Resistance to an Irreversible Second-Generation EGFR Inhibitor 由 Young-Wook Kim, Jeong‐Hun Ko, Zheng-Yun Cui, Amir Abolhoda, Jin Seok Ahn, Sai-Hong Ou, Myung‐Ju Ahn, Keunchil Park

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Pretreatment Epidermal Growth Factor Receptor (<i>EGFR</i>) T790M Mutation Predicts Shorter EGFR Tyrosine Kinase Inhibitor Response Duration in Patients With Non–Small-Cell Lung Ca... 由 Kang‐Yi Su, Hsuan‐Yu Chen, Ker-Chau Li, Min‐Liang Kuo, James Chih‐Hsin Yang, Wing‐Kai Chan, Bing‐Ching Ho, Gee‐Chen Chang, Jin‐Yuan Shih, Sung‐Liang Yu, Pan‐Chyr Yang

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Podoplanin-Positive Cancer-Associated Fibroblasts in the Tumor Microenvironment Induce Primary Resistance to EGFR-TKIs in Lung Adenocarcinoma with EGFR Mutation 由 Tatsuya Yoshida, Genichiro Ishii, Kōichi Goto, Shinya Neri, Hiroko Hashimoto, Kiyotaka Yoh, Seiji Niho, Shigeki Umemura, Shingo Matsumoto, Hironobu Ohmatsu, Shinsuke Iida, Akio Niimi, Kanji Nagai, Yuichiro Ohe, Atsushi Ochiai

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Therapeutic Strategies Utilized in the Setting of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors 由 Helena A. Yu, Gregory J. Riely, Christine M. Lovly

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Maintained Sensitivity to EGFR Tyrosine Kinase Inhibitors in <i>EGFR</i>-Mutant Lung Cancer Recurring after Adjuvant Erlotinib or Gefitinib 由 Geoffrey R. Oxnard, Yelena Y. Janjigian, Maria E. Arcila, Camelia S. Sima, Samantha L. Kass, Gregory J. Riely, William Pao, Mark G. Kris, Marc Ladanyi, Christopher G. Azzoli, Vincent A. Miller

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