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Drug‐conjugated antibodies for the treatment of cancer 著者: John M. Lambert

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Caveolin-1 Dependent Endocytosis Enhances the Chemosensitivity of HER-2 Positive Breast Cancer Cells to Trastuzumab Emtansine (T-DM1) 著者: Yuan‐Chiang Chung, Jang-Fang Kuo, Wan‐Chen Wei, King‐Jen Chang, Wei‐Ting Chao

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Antibody-drug conjugates 著者: Alain Beck, Janice M. Reichert

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Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine‐linked antibody drug conjugate 著者: Julien Marcoux, Thierry Champion, Olivier Colas, Elsa Wagner‐Rousset, Nathalie Corvaı̈a, Alain Van Dorsselaer, Alain Beck, Sarah Cianférani

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Trastuzumab-DM1: A Clinical Update of the Novel Antibody-Drug Conjugate for HER2-Overexpressing Breast Cancer 著者: Myra F. Barginear, Veena John, Daniel R. Budman

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Trastuzumab Emtansine in Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: An Integrated Safety Analysis 著者: Véronique Dièras, Nadia Harbeck, G. Thomas Budd, Joel K. Greenson, Alice E. Guardino, Meghna Samant, Nataliya Chernyukhin, Melanie C. Smitt, Ian E. Krop

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A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer 著者: Brendan C. Bender, Douglas D. Leipold, Keyang Xu, Ben‐Quan Shen, Jay Tibbitts, Lena E. Friberg

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Role of trastuzumab emtansine in the treatment of HER2-positive breast cancer 著者: Drew Oostra, Erin Macrae

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HER2-positive advanced breast cancer: optimizing patient outcomes and opportunities for drug development 著者: Jasmeet Singh, Komal Jhaveri, Francisco J. Esteva

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Ado-trastuzumab emtansine (T-DM1) in human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer: latest evidence and clinical potential 著者: Parvin F. Peddi, Sara A. Hurvitz

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Population pharmacokinetics of trastuzumab emtansine (T-DM1), a HER2-targeted antibody–drug conjugate, in patients with HER2-positive metastatic breast cancer: clinical implication... 著者: Dan Lu, Sandhya Girish, Yuying Gao, Bei Wang, Joo-Hee Yi, Ellie Guardino, Meghna Samant, Melody A. Cobleigh, Mothaffar F. Rimawi, Pierfranco Conté, Jin Y. Jin

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A Phase II Study of Trastuzumab Emtansine in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer Who Were Previously Treated With Trastuzumab,... 著者: Ian E. Krop, Patricia LoRusso, Kathy D. Miller, Shanu Modi, Denise A. Yardley, Gladys Rodriguez, Ellie Guardino, Michael W. Lu, Maoxia Zheng, Sandhya Girish, Lukas C. Amler, Eric P. Winer, Hope S. Rugo

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T-DM1, a novel antibody-drug conjugate, is highly effective against uterine and ovarian carcinosarcomas overexpressing HER2 著者: Roberta Nicoletti, Salvatore Lopez, Stefania Bellone, Emiliano Cocco, Carlton L. Schwab, Jonathan D. Black, Floriana Centritto, Liancheng Zhu, Elena Bonazzoli, Natália Buza, Pei Hui, Delia Mezzanzanica, Silvana Canevari, Peter E. Schwartz, Thomas Rutherford, Alessandro D. Santin

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A phase 1 study of weekly dosing of trastuzumab emtansine (T‐DM1) in patients with advanced human epidermal growth factor 2–positive breast cancer 著者: Muralidhar Beeram, Ian E. Krop, Howard A. Burris, Sandhya Girish, Wei Yu, Michael W. Lu, Scott N. Holden, Shanu Modi

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Targeting of preexisting and induced breast cancer stem cells with trastuzumab and trastuzumab emtansine (T-DM1) 著者: Joachim Diessner, Valentin Bruttel, Roland Stein, Evi Horn, Sebastian Häusler, J. Dietl, A Hönig, Jörg Wischhusen

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HER2-positive gastric cancer 著者: Narikazu Boku

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Phase IIa Trial of Trastuzumab Emtansine With Pertuzumab for Patients With Human Epidermal Growth Factor Receptor 2–Positive, Locally Advanced, or Metastatic Breast Cancer 著者: Kathy D. Miller, Véronique Dièras, Nadia Harbeck, Fabrice André, Reshma Mahtani, Luca Gianni, Kathy S. Albain, Diana Crivellari, Fang Ting Liang, Glenn Michelson, Sanne Lysbet de Haas, Howard A. Burris

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Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability 著者: Kirsten Achilles Poon, Kelly M. Flagella, Joseph C. Beyer, Jay Tibbitts, Surinder Kaur, Ola M. Saad, Joo-Hee Yi, Sandhya Girish, Noël Dybdal, Theresa Reynolds

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Trastuzumab emtansine and stereotactic radiosurgery: an unexpected increase in clinically significant brain edema 著者: Joshua Carlson, Zohra Nooruddin, Chad G. Rusthoven, Anthony Elias, Virginia F. Borges, Jennifer R. Diamond, Brian D. Kavanagh, Peter Kabos

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Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer 著者: Vaishali L. Chudasama, Franziska Schaedeli Stark, John M. Harrold, Jay Tibbitts, Sandhya Girish, Manish Gupta, Norbert Frey, Donald E. Mager

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