Výsledky vyhledávání - Jay Tibbitts

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  1. 1
    Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development

    Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development Autor Jay Tibbitts, David Canter, Ryan Graff, Alison Smith, Leslie A. Khawli

    Vydáno 2015
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  2. 2
    High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production

    High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production Autor Jonathan N. Thon, Matthew T. Devine, Antonija Jurak Begonja, Jay Tibbitts, Joseph E. Italiano

    Vydáno 2012
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  3. 3
    A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer

    A Mechanistic Pharmacokinetic Model Elucidating the Disposition of Trastuzumab Emtansine (T-DM1), an Antibody–Drug Conjugate (ADC) for Treatment of Metastatic Breast Cancer Autor Brendan C. Bender, Douglas D. Leipold, Keyang Xu, Ben‐Quan Shen, Jay Tibbitts, Lena E. Friberg

    Vydáno 2014
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  4. 4
    Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer

    Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer Autor Vaishali L. Chudasama, Franziska Schaedeli Stark, John M. Harrold, Jay Tibbitts, Sandhya Girish, Manish Gupta, Norbert Frey, Donald E. Mager

    Vydáno 2012
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  5. 5
    Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

    Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability Autor Kirsten Achilles Poon, Kelly M. Flagella, Joseph C. Beyer, Jay Tibbitts, Surinder Kaur, Ola M. Saad, Joo-Hee Yi, Sandhya Girish, Noël Dybdal, Theresa Reynolds

    Vydáno 2013
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  6. 6
    Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response

    Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response Autor Harvey Wong, Edna F. Choo, Bruno Alicke, Xiao Ding, Hank La, Erin McNamara, Frank‐Peter Theil, Jay Tibbitts, Lori S. Friedman, Cornelis E. C. A. Hop, Stephen E. Gould

    Vydáno 2012
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  7. 7
    The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates

    The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates Autor Hans K. Erickson, Gail D. Lewis Phillips, Douglas D. Leipold, Carmela A. Provenzano, Elaine Mai, Holly A. Johnson, Bert Gunter, Charlene A. Audette, Manish Gupta, Jan Pinkas, Jay Tibbitts

    Vydáno 2012
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  8. 8
    Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

    Engineered Thio-Trastuzumab-DM1 Conjugate with an Improved Therapeutic Index to Target Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Autor Jagath R. Junutula, Kelly M. Flagella, Richard Graham, Kathryn L. Parsons, Edward Ha, Helga Raab, Sunil Bhakta, Trung Van Nguyen, Debra L. Dugger, Guangmin Li, Elaine Mai, Gail D. Lewis Phillips, Hajime Hiraragi, Reina N. Fuji, Jay Tibbitts, Richard Vandlen, Susan D. Spencer, Richard H. Scheller, Paul Polakis, Mark X. Sliwkowski

    Vydáno 2010
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  9. 9
    Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions

    Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions Autor Omar Qureshi, Tania F. Rowley, Fabian Junker, Shirley J. Peters, Siobhan Crilly, Joanne Compson, Alison Eddleston, Hanna Björkelund, Kevin Greenslade, Michael Parkinson, Nicola L. Davies, Patrick R. Griffin, Thomas L. Pither, Katharine Cain, Louis Christodoulou, Ludovicus Staelens, Emily Ward, Jay Tibbitts, Andrea Kießling, Bryan Smith, Frank R. Brennan, Magnus Malmqvist, Farnaz Fallah‐Arani, David P. Humphreys

    Vydáno 2017
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  10. 10
    Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model

    Effects of Anti-VEGF on Pharmacokinetics, Biodistribution, and Tumor Penetration of Trastuzumab in a Preclinical Breast Cancer Model Autor Cinthia V. Pastuskovas, Eduardo E. Mundo, Simon P. Williams, Tapan K. Nayak, Jason Ho, Sheila Ulufatu, Suzanna Clark, Sarajane Ross, Fang-You Chen, Kathryn Parsons-Reponte, Gary A. Cain, Marjie Van Hoy, Nicholas Majidy, Sheila Bheddah, Josefa Chuh, Katherine R. Kozak, Nicholas Lewin‐Koh, Peter C. Nauka, Daniela Bumbaca, Mark X. Sliwkowski, Jay Tibbitts, Frank‐Peter Theil, Paul J. Fielder, Leslie A. Khawli, C. Andrew Boswell

    Vydáno 2012
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