תוצאות חיפוש

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor מאת Alexei S. Karpov, Payman Amiri, Cornelia Bellamacina, Marie-Hélène Bellance, Werner Breitenstein, Dylan Daniel, Régis Denay, Doriano Fabbro, César Fernández Fernández, Inga Galuba, Stephanie Guerro-Lagasse, Sascha Gutmann, Linda Hinh, Wolfgang Jahnke, Julia Klopp, Albert Lai, Mika Lindvall, Sylvia Ma, Henrik Möbitz, Sabina Pecchi, Gabriele Rummel, Kevin Shoemaker, Joerg Trappe, Charles F. Voliva, Sandra W. Cowan‐Jacob, Andreas L. Marzinzik

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Identification of recurrent <i><scp>FGFR3</scp></i> fusion genes in lung cancer through kinome‐centred <scp>RNA</scp> sequencing מאת Ian J. Majewski, Lorenza Mittempergher, N. Davidson, Astrid Bosma, Stefan M. Willems, Hugo M. Horlings, Iris de Rink, Liliana Greger, Gerrit K. Hooijer, Dennis Peters, Petra M. Nederlof, Ingrid Hofland, Jeroen de Jong, Jelle Wesseling, Roelof J.C. Kluin, Wim Brugman, Ron Kerkhoven, Frank Nieboer, Paul Roepman, Annegien Broeks, Thomas R Muley, Jacek Jassem, Jacek Nikliński, Nico van Zandwijk, Alvis Brāzma, Alicia Oshlack, Michel M. van den Heuvel, René Bernards

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ProKinO: A Unified Resource for Mining the Cancer Kinome מאת Daniel McSkimming, Shima Dastgheib, Eric Talevich, Anish Narayanan, Samiksha Katiyar, Susan S. Taylor, Krys J. Kochut, Natarajan Kannan

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Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes מאת Audrey Sicard, Jean‐Philippe Semblat, Caroline Doerig, Romain Hamelin, Marc Moniatte, Dominique Dorin‐Semblat, Julie A. Spicer, Anubhav Srivastava, Silke Retzlaff, Volker T. Heussler, Andrew P. Waters, Christian Doerig

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Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer מאת Fares Al‐Ejeh, Mariska Miranda, Wei Shi, Peter T. Simpson, Sarah Song, Ana Cristina Vargas, Jodi M. Saunus, Chanel E. Smart, Mythily Mariasegaram, Adrian P. Wiegmans, Georgia Chenevix‐Trench, Sunil R. Lakhani, Kum Kum Khanna

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A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RN... מאת Adriaan H. de Wilde, Kazimier F. Wannee, Florine E. M. Scholte, Jelle J. Goeman, Peter ten Dijke, Eric J. Snijder, Marjolein Kikkert, Martijn J. van Hemert

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Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response מאת Dale Corkery, Alice C. Holly, Sara Lahsaee, Graham Dellaire

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Unmasking Determinants of Specificity in the Human Kinome מאת Pau Creixell, Antonio Palmeri, Chad J. Miller, Hua Jane Lou, Cristina C. Santini, Morten Nielsen, Benjamin E. Turk, Rune Linding

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A high-throughput kinome screen reveals serum/glucocorticoid-regulated kinase 1 as a therapeutic target for NF2-deficient meningiomas מאת Roberta L. Beauchamp, Marianne F. James, Patrick DeSouza, Vilas Wagh, Wen‐Ning Zhao, Justin T. Jordan, Anat Stemmer‐Rachamimov, Scott R. Plotkin, James F. Gusella, Stephen J. Haggarty, Vijaya Ramesh

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<i>Klebsiella pneumoniae</i>targets an EGF receptor-dependent pathway to subvert inflammation מאת Christian Frank, Verónica Reguerio, Marion Rother, David Moranta, André P. Maeurer, Junkal Garmendia, Thomas F. Meyer, José A. Bengoechea

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The Human Kinome and Kinase Inhibition מאת Krisna C. Duong‐Ly, Jeffrey R. Peterson

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KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation מאת Shirish Shukla, Uday Sankar Allam, Aarif Ahsan, Guoan Chen, Pranathi M. Krishnamurthy, Katherine B. Marsh, Matthew Rumschlag, Sunita Shankar, Christopher E. Whitehead, Matthew J. Schipper, Venkatesha Basrur, Daniel R. Southworth, Arul M. Chinnaiyan, Alnawaz Rehemtulla, David G. Beer, Theodore S. Lawrence, Mukesh K. Nyati, Dipankar Ray

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Comprehensive characterization of the Published Kinase Inhibitor Set מאת Jonathan M. Elkins, Vita Fedele, M. Szklarz, K.R. Abdul Azeez, E. Salah, Jowita Mikolajczyk, Sergei Romanov, Nikolai F. Sepetov, Xi‐Ping Huang, Bryan L. Roth, Ayman Al Haj Zen, Denis Fourches, Eugene Muratov, Alex Tropsha, Joel Morris, Beverly A. Teicher, Mark W. Kunkel, Eric C. Polley, Karen Lackey, Francis Atkinson, John P. Overington, Paul Bamborough, Susanne Müller, Daniel J. Price, Timothy M. Willson, David H. Drewry, Stefan Knapp, William J. Zuercher

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Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote מאת Pauline N. Ward, Leila Equinet, Jeremy C.L. Packer, Christian Doerig

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Kinome-wide Decoding of Network-Attacking Mutations Rewiring Cancer Signaling מאת Pau Creixell, Erwin M. Schoof, Craig D. Simpson, James Longden, Chad J. Miller, Hua Jane Lou, Lara Perryman, Thomas R. Cox, Nevena Zivanovic, Antonio Palmeri, Agata Wesolowska‐Andersen, Manuela Helmer‐Citterich, Jesper Ferkinghoff‐Borg, Hiroaki Itamochi, Bernd Bodenmiller, Janine T. Erler, Benjamin E. Turk, Rune Linding

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The Arabidopsis Kinome: phylogeny and evolutionary insights into functional diversification מאת Monika Zulawski, G Schulze, Rostyslav Braginets, Stefanie Hartmann, Waltraud X. Schulze

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A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity מאת Nicholas M. Levinson, Steven G. Boxer

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Kinome-wide shRNA Screen Identifies the Receptor Tyrosine Kinase AXL as a Key Regulator for Mesenchymal Glioblastoma Stem-like Cells מאת Peng Cheng, Emma Phillips, Sung-Hak Kim, David Taylor, Thomas Hielscher, Laura Puccio, Anita B. Hjelmeland, Peter Lichter, Ichiro Nakano, Violaine Goidts

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The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases מאת Ashley A Horton, Bo Wang, Lauren E. Camp, Mark S. Price, Arora Arshi, Máté Nagy, Steven A. Nadler, James R. Faeder, Shirley Luckhart

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Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity מאת Rui Liang, Xiao Li Shen, Boyang Zhang, Yuzhe Li, Wentao Xu, Changhui Zhao, Yunbo Luo, Kunlun Huang

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