Search Results - Patrick C. Fraering

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  1. 1
    Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

    Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase by Eugenio Barone, Sébastien Mosser, Patrick C. Fraering

    Published 2014
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  2. 2
    Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

    Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes by Matthias Cacquevel, Lorène Aeschbach, Jemila Houacine, Patrick C. Fraering

    Published 2012
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  3. 3
    Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

    Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase by Thomas Lemmin, Mitko Dimitrov, Patrick C. Fraering, Matteo Dal Peraro

    Published 2014
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  4. 4
    Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases

    Processing of the Synaptic Cell Adhesion Molecule Neurexin-3β by Alzheimer Disease α- and γ-Secretases by Nathalie Le Bot, Claude Schweizer, Saoussen Ben Halima, Patrick C. Fraering

    Published 2010
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  5. 5
    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

    Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production by Hermeto Gerber, Fang Wu, Mitko Dimitrov, Guillermo Miguel Garcia Osuna, Patrick C. Fraering

    Published 2017
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  6. 6
    The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

    The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides by Gabriele Siegel, Hermeto Gerber, Philipp Koch, Bruestle Oliver, Patrick C. Fraering, Lawrence Rajendran

    Published 2017
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  7. 7
    Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores

    Electron microscopic structure of purified, active γ-secretase reveals an aqueous intramembrane chamber and two pores by Vlado K. Lazarov, Patrick C. Fraering, Wenjuan Ye, Michael S. Wolfe, Dennis J. Selkoe, Huilin Li

    Published 2006
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  8. 8
    γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site

    γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site by Patrick C. Fraering, Wenjuan Ye, Matthew J. LaVoie, Beth L. Ostaszewski, Dennis J. Selkoe, Michael S. Wolfe

    Published 2005
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  9. 9
    The GPI Transamidase Complex of<i>Saccharomyces cerevisiae</i>Contains Gaa1p, Gpi8p, and Gpi16p

    The GPI Transamidase Complex of<i>Saccharomyces cerevisiae</i>Contains Gaa1p, Gpi8p, and Gpi16p by Patrick C. Fraering, Isabella Imhof, Urs Meyer, Jean‐Marc Strub, Alain Van Dorsselaer, Christine Vionnet, Andreas Conzelmann

    Published 2001
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  10. 10
    Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin

    Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin by Matthew J. LaVoie, Patrick C. Fraering, Beth L. Ostaszewski, Wenjuan Ye, W. Taylor Kimberly, Michael S. Wolfe, Dennis J. Selkoe

    Published 2003
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  11. 11
    Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution

    Cryoelectron Microscopy Structure of Purified γ-Secretase at 12 Å Resolution by Pamela Osenkowski, Hua Li, Wenjuan Ye, Dongyang Li, Lorène Aeschbach, Patrick C. Fraering, Michael S. Wolfe, Dennis J. Selkoe, Huilin Li

    Published 2008
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  12. 12
    Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells

    Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells by Yinzhong Lu, Jun Wan, Zhifeng Yang, Xiling Lei, Qi Niu, Lanxin Jiang, Willemijn M. Passtoors, Aiping Zang, Patrick C. Fraering, Fang Wu

    Published 2016
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  13. 13
    Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

    Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production by Mitko Dimitrov, Jean-René Alattia, Thomas Lemmin, Rajwinder Lehal, Andrzej Fligier, Jemila Houacine, Ishrut Hussain, Freddy Radtke, Matteo Dal Peraro, Dirk Beher, Patrick C. Fraering

    Published 2013
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  14. 14
    Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa

    Discovery of a Novel Pharmacological and Structural Class of Gamma Secretase Modulators Derived from the Extract of Actaea racemosa by Mark A. Findeis, Frank C. Schroeder, Timothy D. McKee, Debra Yager, Patrick C. Fraering, Steffen P. Creaser, Wesley Austin, Jon Clardy, Rong Wang, Dennis J. Selkoe, Christopher B. Eckman

    Published 2012
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  15. 15
    Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence

    Inhibition of Notch pathway arrests PTEN-deficient advanced prostate cancer by triggering p27-driven cellular senescence by Ajinkya Revandkar, Maria Luna Perciato, Alberto Toso, Abdullah Alajati, Jingjing Chen, Hermeto Gerber, Mitko Dimitrov, Andrea Rinaldi, Nicolas Delaleu, Emiliano Pasquini, Rocco D’Antuono, Sandra Pinton, Marco Losa, Letizia Gnetti, Alberto J. Arribas, Patrick C. Fraering, Francesco Bertoni, Alain Nepveu, Andrea Alimonti

    Published 2016
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  16. 16
    Substrate-targeting γ-secretase modulators

    Substrate-targeting γ-secretase modulators by Thomas Kukar, Thomas B. Ladd, Maralyssa Bann, Patrick C. Fraering, Rajeshwar Narlawar, Ghulam M. Maharvi, Brent Healy, Robert Chapman, Alfred T. Welzel, Robert Price, Brenda D. Moore, Vijayaraghavan Rangachari, Bernadette Cusack, Jason L. Eriksen, Karen Jansen‐West, Christophe Verbeeck, Debra Yager, Christopher B. Eckman, Wenjuan Ye, Sarah A. Sagi, Barbara A. Cottrell, Justin W. Torpey, Terrone L. Rosenberry, Abdul H. Fauq, Michael S. Wolfe, Boris Schmidt, Dominic M. Walsh, Edward H. Koo, Todd E. Golde

    Published 2008
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