Resultados de procura

Overexpression of Amyloid-β Protein Precursor Induces Mitochondrial Oxidative Stress and Activates the Intrinsic Apoptotic Cascade por Matthew G. Bartley, Kristin Marquardt, Danielle Kirchhof, Heather Wilkins, David Patterson, Daniel A. Linseman

Ligazón do recurso

Alzheimer's Disease por Mark Bothwell, Edward Giniger

Ligazón do recurso Ligazón do recurso

Review article What causes alzheimer’s disease? por Richard A. Armstrong

Ligazón do recurso Ligazón do recurso

A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences por Yat Fung Shea, Leung‐Wing Chu, Angel On-Kei Chan, Joyce Ha, Yan Li, You‐Qiang Song

Ligazón do recurso

One-Carbon Metabolism and Alzheimers Disease: Focus on Epigenetics por Fabio Coppedè

Ligazón do recurso

Membrane Topology of γ-Secretase Component PEN-2 por Adam S. Crystal, Vanessa A. Morais, Theodore C. Pierson, Donald S. Pijak, Dan Carlin, Virginia M.‐Y. Lee, Robert W. Doms

Ligazón do recurso Ligazón do recurso

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis por Lin Teng, Jian Zhao, Feifei Wang, Lan Ma, Gang Pei

Ligazón do recurso Ligazón do recurso

Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease por Yitshak I. Francis, Mauro Fà, Haider Ashraf, Hong Zhang, Agnieszka Staniszewski, David S. Latchman, Ottavio Arancio

Ligazón do recurso

Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate por William P. Esler, W. Taylor Kimberly, Beth L. Ostaszewski, Wenjuan Ye, Thekla S. Diehl, Dennis J. Selkoe, Michael S. Wolfe

Ligazón do recurso

Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins por Wanjiang Zhang, Sang Woo Han, Daniel W. McKeel, Alison Goate, Jane Y. Wu

Ligazón do recurso Ligazón do recurso

Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen‐2) demonstrate excessive p53‐dependent apoptosis and neuronal loss por William A. Campbell, Hongwei Yang, Henrik Zetterberg, Stéphanie Baulac, Jacqueline A. Sears, Tianming Liu, Stephen T.C. Wong, Tao Zhong, Weiming Xia

Ligazón do recurso Ligazón do recurso

REVIEW: γ‐Secretase Inhibitors for the Treatment of Alzheimer's Disease: The Current State por Francesco Panza, Vincenza Frisardi, Bruno P. Imbimbo, Cristiano Capurso, Giancarlo Logroscino, Daniele Sancarlo, Davide Seripa, Gianluigi Vendemiale, Alberto Pilotto, Vincenzo Solfrizzi

Ligazón do recurso Ligazón do recurso

Alzheimer’s disease: epidemiology, genetics, and beyond por Xiaoping Wang, Hongliu Ding

Ligazón do recurso

Aging Increased Amyloid Peptide and Caused Amyloid Plaques in Brain of Old APP/V717I Transgenic Mice by a Different Mechanism than Mutant Presenilin1 por Ilse Dewachter, Jo Van Dorpe, Liesbet Smeijers, Martine Gilis, Cuno Kuipéri, Isabelle Laenen, Nathalie Caluwaerts, Dieder Moechars, Frédéric Checler, Hugo Vanderstichele, Fred Van Leuven

Ligazón do recurso Ligazón do recurso

Ca²⁺ dysregulation in neurons from transgenic mice expressing mutant presenilin 2 por Maulilio J. Kipanyula, Laura Contreras, Enrico Zampese, Cristian Lazzari, Andrea Wong, Paola Pizzo, Cristina Fasolato, Tullio Pozzan

Ligazón do recurso Ligazón do recurso

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase por Eva Czirr, Barbara A. Cottrell, Stefanie Leuchtenberger, Thomas Kukar, Thomas B. Ladd, Hermann Esselmann, Sabine Paul, Robert Schubenel, Justin W. Torpey, Claus U. Pietrzik, Todd E. Golde, Jens Wiltfang, Karlheinz Baumann, Edward H. Koo, Sascha Weggen

Ligazón do recurso Ligazón do recurso

Reexamining Alzheimer's Disease: Evidence for a Protective Role for Amyloid-β Protein Precursor and Amyloid-β por Rudy J. Castellani, Hyoung‐gon Lee, Sandra L. Siedlak, Akihiko Nunomura, Takaaki Hayashi, Masao Nakamura, Xiongwei Zhu, George Perry, Mark A. Smith

Ligazón do recurso

Folate deprivation increases presenilin expression, gamma‐secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary <i>S</i>‐... por Amy Chan, Thomas B. Shea

Ligazón do recurso Ligazón do recurso

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential por Stefan F. Lichtenthaler

Ligazón do recurso Ligazón do recurso

Three-dimensional structure of human γ-secretase por Peilong Lu, Xiao‐chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres, Yigong Shi

Ligazón do recurso