Výsledky vyhledávání - Joshua A. Bittker

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  1. 1
    Nucleic acid evolution and minimization by nonhomologous random recombination

    Nucleic acid evolution and minimization by nonhomologous random recombination Autor Joshua A. Bittker, Brian V. Le, David R. Liu

    Vydáno 2002
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  2. 2
    Development of small-molecule probes that selectively kill cells induced to express mutant RAS

    Development of small-molecule probes that selectively kill cells induced to express mutant RAS Autor Michel Weïwer, Joshua A. Bittker, Timothy A. Lewis, Kaoru Shimada, Wan Seok Yang, Lawrence MacPherson, Sivaraman Dandapani, Michelle Palmer, Brent R. Stockwell, Stuart L. Schreiber, Benito Muñoz

    Vydáno 2011
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  3. 3
    Small-molecule inducers of insulin expression in pancreatic α-cells

    Small-molecule inducers of insulin expression in pancreatic α-cells Autor Dina Fomina‐Yadlin, Stefan Kubicek, Deepika Walpita, Vlado Dančík, Jacob Hecksher‐Sørensen, Joshua A. Bittker, Tanaz Sharifnia, Alykhan F. Shamji, Paul A. Clemons, Bridget K. Wagner, Stuart L. Schreiber

    Vydáno 2010
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  4. 4
    Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis

    Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis Autor Sae Woong Park, Dominick Casalena, Daniel J. Wilson, R. Dai, Partha P. Nag, Feng Liu, Jim P. Boyce, Joshua A. Bittker, Stuart L. Schreiber, B.C. Finzel, Dirk Schnappinger, Courtney C. Aldrich

    Vydáno 2014
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  5. 5
    High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

    High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding Autor Wei‐Chung Chiang, Yongjie Wei, Yi-Chun Kuo, Shuguang Wei, Anwu Zhou, Zhongju Zou, Jenna Yehl, Matthew J. Ranaghan, Adam Skepner, Joshua A. Bittker, José R. Perez, Bruce A. Posner, Beth Levine

    Vydáno 2018
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  6. 6
    The Drug Repurposing Hub: a next-generation drug library and information resource

    The Drug Repurposing Hub: a next-generation drug library and information resource Autor Steven M. Corsello, Joshua A. Bittker, Zihan Liu, Joshua Gould, Patrick McCarren, Jodi Hirschman, Stephen Johnston, Anita Vrcic, Bang Wong, Mariya Khan, Jacob K. Asiedu, Rajiv Narayan, Christopher C. Mader, Aravind Subramanian, Todd R. Golub

    Vydáno 2017
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  7. 7
    Evolving BioAssay Ontology (BAO): modularization, integration and applications

    Evolving BioAssay Ontology (BAO): modularization, integration and applications Autor Saminda Abeyruwan, Uma D. Vempati, Hande Küçük‐McGinty, Ubbo Visser, Amar Koleti, Ahsan Mir, Kunie Sakurai, Caty Chung, Joshua A. Bittker, Paul A. Clemons, Steve Brudz, Anosha D. Siripala, Arturo J. Morales, Martin Romacker, David Twomey, Svetlana Bureeva, Vance Lemmon, Stephan C. Schürer

    Vydáno 2014
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  8. 8
    Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

    Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease Autor Elizaveta S. Leshchiner, Jason S. Rush, Michael A. Durney, Zhifang Cao, Vlado Dančík, Benjamin Chittick, Huixian Wu, Adam Petrone, Joshua A. Bittker, Andrew J. Phillips, José R. Perez, Alykhan F. Shamji, Virendar K. Kaushik, Mark J. Daly, Daniel B. Graham, Stuart L. Schreiber, Ramnik J. Xavier

    Vydáno 2017
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  9. 9
    A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay

    A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay Autor Mark‐Anthony Bray, Sigrun Gustafsdottir, Mohammad Hossein Rohban, Shantanu Singh, Vebjorn Ljosa, Katherine L Sokolnicki, Joshua A. Bittker, Nicole E. Bodycombe, Vlado Dančík, Thomas P. Hasaka, Cindy Hon, Melissa M. Kemp, Kejie Li, Deepika Walpita, Mathias J. Wawer, Todd R. Golub, Stuart L. Schreiber, Paul A. Clemons, Alykhan F. Shamji, Anne E. Carpenter

    Vydáno 2017
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  10. 10
    Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes

    Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes Autor Kfir Sharabi, Hua Lin, Clint D.J. Tavares, John E. Dominy, João Paulo Camporez, Rachel J. Perry, Roger Schilling, Amy K. Rines, Jaemin Lee, Marc Hickey, Melissa Bennion, Michelle Palmer, Partha P. Nag, Joshua A. Bittker, José R. Perez, Mark P. Jedrychowski, Umut Özcan, Steve P. Gygi, Theodore M. Kamenecka, Gerald I. Shulman, Stuart L. Schreiber, Patrick R. Griffin, Pere Puigserver

    Vydáno 2017
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  11. 11
    Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

    Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling Autor Mathias J. Wawer, Kejie Li, Sigrun Gustafsdottir, Vebjorn Ljosa, Nicole E. Bodycombe, Melissa A. Marton, Katherine L Sokolnicki, Mark‐Anthony Bray, Melissa M. Kemp, Ellen Winchester, Bradley R Taylor, George Grant, C. Suk-Yee Hon, Jeremy R. Duvall, Joshua Wilson, Joshua A. Bittker, Vlado Dančík, Rajiv Narayan, Aravind Subramanian, Wendy Winckler, Todd R. Golub, Anne E. Carpenter, Alykhan F. Shamji, Stuart L. Schreiber, Paul A. Clemons

    Vydáno 2014
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  12. 12
    Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

    Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset Autor Brinton Seashore‐Ludlow, Matthew G. Rees, Jaime H. Cheah, Murat Cokol, Edmund V. Price, Matthew E. Coletti, Victor Jones, Nicole E. Bodycombe, Christian K. Soule, Joshua Gould, Benjamin Alexander, Ava Li, Philip Montgomery, Mathias J. Wawer, Nurdan Kuru, Joanne Kotz, C. Suk-Yee Hon, Benito Muñoz, Ted Liefeld, Vlado Dančík, Joshua A. Bittker, Michelle Palmer, James E. Bradner, Alykhan F. Shamji, Paul A. Clemons, Stuart L. Schreiber

    Vydáno 2015
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  13. 13
    Correlating chemical sensitivity and basal gene expression reveals mechanism of action

    Correlating chemical sensitivity and basal gene expression reveals mechanism of action Autor Matthew G. Rees, Brinton Seashore‐Ludlow, Jaime H. Cheah, Drew Adams, Edmund V. Price, Shubhroz Gill, Sarah Javaid, Matthew E. Coletti, Victor Jones, Nicole E. Bodycombe, Christian K. Soule, Benjamin Alexander, Ava Li, Philip Montgomery, Joanne Kotz, C. Suk-Yee Hon, Benito Muñoz, Ted Liefeld, Vlado Dančík, Daniel A. Haber, Clary B. Clish, Joshua A. Bittker, Michelle Palmer, Bridget K. Wagner, Paul A. Clemons, Alykhan F. Shamji, Stuart L. Schreiber

    Vydáno 2015
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  14. 14
    Genetic and transcriptional evolution alters cancer cell line drug response

    Genetic and transcriptional evolution alters cancer cell line drug response Autor Uri Ben‐David, Benjamin A. Siranosian, Gavin Ha, Helen Tang, Yaara Oren, Kunihiko Hinohara, Craig A. Strathdee, Joshua M. Dempster, Nicholas Lyons, Robert Burns, Anwesha Nag, Guillaume Kugener, Beth A. Cimini, Peter Tsvetkov, Yosef E. Maruvka, Ryan O’Rourke, Anthony J. Garrity, Andrew A. Tubelli, Pratiti Bandopadhayay, Aviad Tsherniak, Francisca Vázquez, Bang Wong, Chet Birger, Mahmoud Ghandi, Aaron R. Thorner, Joshua A. Bittker, Matthew Meyerson, Gad Getz, Rameen Beroukhim, Todd R. Golub

    Vydáno 2018
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  15. 15
    An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

    An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules Autor Amrita Basu, Nicole E. Bodycombe, Jaime H. Cheah, Edmund V. Price, Ke Liu, Giannina I. Schaefer, Richard Y. Ebright, Michelle L. Stewart, Daisuke Ito, Stephanie Wang, Abigail Bracha, Ted Liefeld, Mathias J. Wawer, Joshua C. Gilbert, Andrew J. Wilson, Nicolas Stransky, Gregory V. Kryukov, Vlado Dančík, Jordi Barretina, Levi A. Garraway, C. Suk-Yee Hon, Benito Muñoz, Joshua A. Bittker, Brent R. Stockwell, Dineo Khabele, Andrew M. Stern, Paul A. Clemons, Alykhan F. Shamji, Stuart L. Schreiber

    Vydáno 2013
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  16. 16
    Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

    Discovering the anticancer potential of non-oncology drugs by systematic viability profiling Autor Steven M. Corsello, Rohith T. Nagari, Ryan D. Spangler, Jordan Rossen, Mustafa Kocak, Jordan Bryan, Ranad Humeidi, D. D. Peck, Xiaoyun Wu, Andrew Tang, Vickie M. Wang, Samantha Bender, Evan Lemire, Rajiv Narayan, Philip Montgomery, Uri Ben‐David, Colin W. Garvie, Yejia Chen, Matthew G. Rees, Nicholas Lyons, James M. McFarland, Bang Wong, Li Wang, Nancy Dumont, Patrick J. O’Hearn, Eric Stefan, John G. Doench, Caitlin Harrington, Heidi Greulich, Matthew Meyerson, Francisca Vázquez, Aravind Subramanian, Jennifer A. Roth, Joshua A. Bittker, Jesse S. Boehm, Christopher C. Mader, Aviad Tsherniak, Todd R. Golub

    Vydáno 2020
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  17. 17
    Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

    Niche-based screening identifies small-molecule inhibitors of leukemia stem cells Autor Kimberly A. Hartwell, Peter G. Miller, Siddhartha Mukherjee, Alissa R. Kahn, Alison L. Stewart, David J. Logan, Joseph Negri, Mildred Duvet, Marcus Järås, Rishi V. Puram, Vlado Dančík, Fátima Al‐Shahrour, Thomas Kindler, Zuzana Tóthová, Shrikanta Chattopadhyay, Thomas P. Hasaka, Rajiv Narayan, Mingji Dai, Christina Huang, Sebastian Shterental, Lisa P. Chu, J. Erika Haydu, Jae Hung Shieh, David P. Steensma, Benito Muñoz, Joshua A. Bittker, Alykhan F. Shamji, Paul A. Clemons, Nicola Tolliday, Anne E. Carpenter, D. Gary Gilliland, Andrew M. Stern, Malcolm A.S. Moore, David T. Scadden, Stuart L. Schreiber, Benjamin L. Ebert, Todd R. Golub

    Vydáno 2013
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  18. 18
    A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles

    A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles Autor Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, D. D. Peck, Ted Natoli, Xiaodong Lü, Joshua Gould, John F. Davis, Andrew A. Tubelli, Jacob K. Asiedu, David L. Lahr, Jodi Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C. P. Smith, Daniel D. Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M. Enache, Federica Piccioni, Alice H. Berger, Alykhan F. Shamji, Angela N. Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y. Takeda, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Nathanael S. Gray, Paul A. Clemons, Serena J. Silver, Xiaoyun Wu, Wen‐Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J. Haggarty, Lucienne Ronco, Jesse S. Boehm, Stuart L. Schreiber, John G. Doench, Joshua A. Bittker, David E. Root, Bang Wong, Todd R. Golub

    Vydáno 2017
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  19. 19
    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

    Diversity-oriented synthesis yields novel multistage antimalarial inhibitors Autor Nobutaka Kato, Eamon Comer, Tomoyo Sakata‐Kato, Arvind Sharma, Manmohan Sharma, Micah Maetani, Jessica Bastien, Nicolas M. B. Brancucci, Joshua A. Bittker, Victoria Corey, David C. Clarke, Emily R. Derbyshire, Gillian L. Dornan, Sandra Duffy, Sean Eckley, Maurice A. Itoe, Karin M. J. Koolen, Timothy A. Lewis, Ping S. Lui, Amanda K. Lukens, Emily Lund, Sandra March, Elamaran Meibalan, Bennett C. Meier, Jacob A. McPhail, Branko Mitasev, Eli L. Moss, Morgane Sayes, Yvonne Van Gessel, Mathias J. Wawer, Takashi Yoshinaga, Anne‐Marie Zeeman, Vicky M. Avery, Sangeeta N. Bhatia, John E. Burke, Flaminia Catteruccia, Jon Clardy, Paul A. Clemons, Koen J. Dechering, Jeremy R. Duvall, Michael A. Foley, Fabian Gusovsky, Clemens H. M. Kocken, Matthias Marti, Marshall Morningstar, Benito Muñoz, Daniel E. Neafsey, Amit Sharma, Elizabeth A. Winzeler, Dyann F. Wirth, Christina Scherer, Stuart L. Schreiber

    Vydáno 2016
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  20. 20
    A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

    A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles Autor Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, D. D. Peck, Ted Natoli, Xiaodong Lü, Joshua Gould, John F. Davis, Andrew A. Tubelli, Jacob K. Asiedu, David L. Lahr, Jodi Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C. P. Smith, Daniel D. Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M. Enache, Federica Piccioni, Sarah Johnson, Nicholas Lyons, Alice H. Berger, Alykhan F. Shamji, Angela N. Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y. Takeda, Roger Hu, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Peyton Greenside, Nathanael S. Gray, Paul A. Clemons, Serena J. Silver, Xiaoyun Wu, Wen‐Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J. Haggarty, Lucienne Ronco, Jesse S. Boehm, Stuart L. Schreiber, John G. Doench, Joshua A. Bittker, David E. Root, Bang Wong, Todd R. Golub

    Vydáno 2017
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