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  1. 1
    Challenges and Opportunities in Targeting the Menin–MLL Interaction

    Challenges and Opportunities in Targeting the Menin–MLL Interaction Autor Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2014
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  2. 2
    Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?

    Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? Autor Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2014
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  3. 3
    H3K36 Methyltransferases as Cancer Drug Targets: Rationale and Perspectives for Inhibitor Development

    H3K36 Methyltransferases as Cancer Drug Targets: Rationale and Perspectives for Inhibitor Development Autor David Rogawski, Jolanta Grembecka, Tomasz Cierpicki

    Vydáno 2016
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  4. 4
    Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction

    Molecular Basis of the Mixed Lineage Leukemia-Menin Interaction Autor Jolanta Grembecka, Amalia Marie Belcher, Thomas Hartley, Tomasz Cierpicki

    Vydáno 2010
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  5. 5
    Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein

    Crystal Structure of Menin Reveals Binding Site for Mixed Lineage Leukemia (MLL) Protein Autor Marcelo J. Murai, M. Chruszcz, Gireesh Reddy, Jolanta Grembecka, Tomasz Cierpicki

    Vydáno 2011
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  6. 6
    Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes

    Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein–Ligand Complexes Autor Jonathan Pollock, Dmitry Borkin, George Lund, Trupta Purohit, Edyta Dyguda‐Kazimierowicz, Jolanta Grembecka, Tomasz Cierpicki

    Vydáno 2015
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  7. 7
    Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of <i>PEG10</i> and Blocks Hepatocellular Carcinoma

    Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of <i>PEG10</i> and Blocks Hepatocellular Carcinoma Autor Katarzyna Kempińska, Bhavna Malik, Dmitry Borkin, Szymon Kłossowski, Shirish Shukla, Hongzhi Miao, Jingya Wang, Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2017
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  8. 8
    Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

    Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia Autor Aibin Shi, Marcelo J. Murai, Shihan He, George Lund, Thomas Hartley, Trupta Purohit, Gireesh Reddy, M. Chruszcz, Jolanta Grembecka, Tomasz Cierpicki

    Vydáno 2012
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  9. 9
    Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia

    Structure of the MLL CXXC domain–DNA complex and its functional role in MLL-AF9 leukemia Autor Tomasz Cierpicki, Laurie E. Risner, Jolanta Grembecka, Stephen M. Lukasik, Relja Popovic, Monika Omonkowska, David Shultis, Nancy J. Zeleznik‐Le, John H. Bushweller

    Vydáno 2009
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  10. 10
    MLL protects CpG clusters from methylation within the <i>Hoxa9</i> gene, maintaining transcript expression

    MLL protects CpG clusters from methylation within the <i>Hoxa9</i> gene, maintaining transcript expression Autor Frank Erfurth, Relja Popovic, Jolanta Grembecka, Tomasz Cierpicki, Catherine Theisler, Zhen-Biao Xia, Tara Stuart, Manuel O. Dı́az, John H. Bushweller, Nancy J. Zeleznik‐Le

    Vydáno 2008
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  11. 11
    High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

    High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction Autor Shihan He, Timothy J. Senter, Jonathan Pollock, Changho Han, Sunil Upadhyay, Trupta Purohit, Rocco D. Gogliotti, Craig W. Lindsley, Tomasz Cierpicki, Shaun R. Stauffer, Jolanta Grembecka

    Vydáno 2014
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  12. 12
    Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

    Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) Autor Dmitry Borkin, Jonathan Pollock, Katarzyna Kempińska, Trupta Purohit, Xiaoqin Li, Bo Wen, Ting Zhao, Hongzhi Miao, Shirish Shukla, Miao He, Duxin Sun, Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2016
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  13. 13
    BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

    BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization Autor Felicia Gray, Hyo Je Cho, Shirish Shukla, Shihan He, Ashley Harris, Bohdan Boytsov, Łukasz Jaremko, Mariusz Jaremko, Borries Demeler, Elizabeth R. Lawlor, Jolanta Grembecka, Tomasz Cierpicki

    Vydáno 2016
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  14. 14
    Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer

    Genome-scale CRISPR-Cas9 screen of Wnt/β-catenin signaling identifies therapeutic targets for colorectal cancer Autor Chunhua Wan, Sylvia Mahara, Claire Sun, Anh Doan, H. Chua, Dakang Xu, Jia Bian, Yue Li, Danxi Zhu, Dhanya Sooraj, Tomasz Cierpicki, Jolanta Grembecka, Ron Firestein

    Vydáno 2021
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  15. 15
    Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction

    Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction Autor Dmitry Borkin, Szymon Kłossowski, Jonathan Pollock, Hongzhi Miao, Brian M. Linhares, Katarzyna Kempińska, Zhuang Jin, Trupta Purohit, Bo Wen, Miao He, Duxin Sun, Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2018
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  16. 16
    Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells

    Ash1l controls quiescence and self-renewal potential in hematopoietic stem cells Autor Morgan Jones, Jennifer Chase, Michelle L. Brinkmeier, Jing Xu, Daniel N. Weinberg, Julien Schira, Ann Friedman, Sami N. Malek, Jolanta Grembecka, Tomasz Cierpicki, Yali Dou, Sally A. Camper, Ivan Maillard

    Vydáno 2015
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  17. 17
    Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

    Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia Autor Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G. Muntean, Roderick J. Sorenson, Hollis D. Showalter, Marcelo J. Murai, Amalia Marie Belcher, Thomas Hartley, Jay L. Hess, Tomasz Cierpicki

    Vydáno 2012
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  18. 18
    A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

    A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice Autor Anuradha Illendula, John Anto Pulikkan, Hongliang Zong, Jolanta Grembecka, Liting Xue, Siddhartha Sen, Yunpeng Zhou, Adam Boulton, Aravinda Kuntimaddi, Yan Gao, Roger A. Rajewski, Mónica L. Guzmán, Lucio H. Castilla, John H. Bushweller

    Vydáno 2015
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  19. 19
    Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner

    Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner Autor Shihan He, B. S. Malik, Dmitry Borkin, Hongzhi Miao, Sudhanshu Shukla, Katarzyna Kempińska, Tanaya A. Purohit, Jingya Wang, L Chen, Brian Parkin, Sami N. Malek, Gwenn Danet-Desnoyers, Andrew G. Muntean, Tomasz Cierpicki, Jolanta Grembecka

    Vydáno 2015
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  20. 20
    Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

    Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes Autor Nicolai A. Kittan, Ronald M. Allen, Abhay Dhaliwal, Karen A. Cavassani, Matthew Schaller, Katherine Gallagher, William F. Carson, Sumanta Mukherjee, Jolanta Grembecka, Tomasz Cierpicki, Gábor Járai, John Westwick, Steven L. Kunkel, Cory M. Hogaboam

    Vydáno 2013
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