Хайлтын үр дүнгүүд

Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer -н Adam R. Blanden, Xin Yu, Stewart N. Loh, Arnold J. Levine, Darren R. Carpizo

Бүрэн текст авах

Structure of <scp>C</scp>lass <scp>B GPCRs</scp>: new horizons for drug discovery -н Andrea Bortolato, A.S. Dore, Kaspar Hollenstein, Benjamin G. Tehan, Jonathan S. Mason, Fiona H. Marshall

Бүрэн текст авах

Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: <scp>IUPHAR R</scp>eview 12 -н Janet J. Maguire, Anthony P. Davenport

Бүрэн текст авах Бүрэн текст авах

A Research Agenda for Malaria Eradication: Basic Science and Enabling Technologies

Бүрэн текст авах Бүрэн текст авах

Unfolded protein response to autophagy as a promising druggable target for anticancer therapy -н Dong Hoon Suh, Mi‐Kyung Kim, Hee Seung Kim, Hyun Hoon Chung, Yong Sang Song

Бүрэн текст авах

The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro -н Olga Piskareva, Harry Harvey, John Nolan, Ross Conlon, Leah Alcock, Patrick G. Buckley, Paul Dowling, Michael Henry, Finbarr O’Sullivan, Isabella Bray, Raymond L. Stallings

Бүрэн текст авах

An integrated structural proteomics approach along the druggable genome of Corynebacterium pseudotuberculosis species for putative druggable targets -н Leandro G. Radusky, Syed Shah Hassan, Esteban Lanzarotti, Sandeep Tiwari, Syed Babar Jamal, Javed Ali, Amjad Ali, Rafaela Salgado Ferreira, Debmalya Barh, Artur Silva, Adrián G. Turjanski, Vasco Azevedo

Бүрэн текст авах Бүрэн текст авах

Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC) -н Nesaretnam Barr Kumarakulasinghe, Nico van Zanwijk, Ross A. Soo

Бүрэн текст авах Бүрэн текст авах

A microRNA code for prostate cancer metastasis -н Désirée Bonci, Valeria Coppola, Michele Patrizii, Antonio Addario, Alessio Cannistraci, Federica Francescangeli, Raffaella Pecci, Giovanni Muto, Devis Collura, R. Bedini, Ann Zeuner, M Valtieri, Steno Sentinelli, Maria Serena Benassi, Michele Gallucci, Paolo Carlini, Stefano Piccolo, Ruggero De Maria

Бүрэн текст авах Бүрэн текст авах

Mapping the Druggable Allosteric Space of G‐Protein Coupled Receptors: a Fragment‐Based Molecular Dynamics Approach -н Anthony Ivetac, J. Andrew McCammon

Бүрэн текст авах Бүрэн текст авах

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets -н Joost C.M. Uitdehaag, Folkert Verkaar, Husam Alwan, Jos de Man, Rogier C. Buijsman, Guido J.R. Zaman

Бүрэн текст авах

Machine learning models identify molecules active against the Ebola virus in vitro -н Sean Ekins, Joel S. Freundlich, Alex M. Clark, Manu Anantpadma, Robert A. Davey, Peter B. Madrid

Бүрэн текст авах Бүрэн текст авах

A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells -н Micah J. Niphakis, Kenneth M. Lum, Armand B. Cognetta, Bruno E. Correia, Taka-Aki Ichu, José Olucha, Steven J Brown, Soumajit Kundu, Fabiana Piscitelli, Hugh Rosen, Benjamin F. Cravatt

Бүрэн текст авах Бүрэн текст авах

Nucleocapsid Protein: A Desirable Target for Future Therapies Against HIV-1 -н Mattia Mori, Lesia Kovalenko, Sébastien Lyonnais, Danny Antaki, Bruce E. Torbett, Maurizio Botta, Gilles Mirambeau, Yves Mély

Бүрэн текст авах

Integrated Approaches for Genome-wide Interrogation of the Druggable Non-olfactory G Protein-coupled Receptor Superfamily -н Bryan L. Roth, Wesley K. Kroeze

Бүрэн текст авах

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity -н Bret D. Wallace, Adam Roberts, Rebecca M. Pollet, James D. Ingle, Kristen A. Biernat, Samuel J. Pellock, Madhu Kumar Venkatesh, Leah Guthrie, Sara O’Neal, Sara J. Robinson, Makani Dollinger, Esteban G. Figueroa, Sarah R. McShane, Rachel D. Cohen, Jian Jin, Stephen V. Frye, William C. Zamboni, Charles Pepe‐Ranney, Sridhar Mani, Libusha Kelly, Matthew R. Redinbo

Бүрэн текст авах

SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets -н Jing Guo, Hui Liu, Jie Zheng

Бүрэн текст авах Бүрэн текст авах

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts -н David Roulois, Helen Loo Yau, Rajat Singhania, Yadong Wang, Arnavaz Danesh, Shu Yi Shen, Han Han, Gangning Liang, Peter A. Jones, Trevor J. Pugh, Catherine O’Brien, Daniel D. De Carvalho

Бүрэн текст авах Бүрэн текст авах

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted t... -н Elisa Donnard, Paula Fontes Asprino, Bruna Corrêa, Fabiana Bettoni, Fernanda Christtanini Koyama, Fábio C. P. Navarro, Rodrigo Oliva Perez, John M. Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L. Jardim, Luiz F. L. Reis, Raphael B. Parmigiani, Pedro A. F. Galante, Anamaria A. Camargo

Бүрэн текст авах Бүрэн текст авах

Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors. -н Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo

Бүрэн текст авах Бүрэн текст авах