Resultados de búsqueda - J. David Lawson

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  1. 1
    Protein flexibility and intrinsic disorder

    Protein flexibility and intrinsic disorder por Predrag Radivojac, Zoran Obradović, David K. Smith, Guang Zhu, Slobodan Vučetić, Celeste J. Brown, J. David Lawson, A. Keith Dunker

    Publicado 2003
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  2. 2
    Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase

    Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase por Christopher R. Smith, D.R. Dougan, Mallareddy Komandla, Toufike Kanouni, Beverly Knight, J. David Lawson, M. Sabat, Ewan R. Taylor, Phong Vu, Corey Wyrick

    Publicado 2015
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  3. 3
    DisProt: a database of protein disorder

    DisProt: a database of protein disorder por Slobodan Vučetić, Zoran Obradović, Vladimir Vacic, Predrag Radivojac, Kang Peng, Lilia M. Iakoucheva, Marc S. Cortese, J. David Lawson, Celeste J. Brown, Jason G. Sikes, Crystal D. Newton, A. Keith Dunker

    Publicado 2004
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  4. 4
    Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i>-Deleted Cancers

    Fragment-Based Discovery of MRTX1719, a Synthetic Lethal Inhibitor of the PRMT5•MTA Complex for the Treatment of <i>MTAP</i>-Deleted Cancers por Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski, David M. Briere, Aaron C. Burns, James G. Christensen, Jeffery Clarine, Lars D. Engstrom, Robin J. Gunn, Anthony Ivetac, Ronald Jean-Baptiste, John M. Ketcham, Masakazu Kobayashi, Jon Kuehler, Svitlana Kulyk, J. David Lawson, Krystal Moya, Peter Olson, Lisa Rahbæk, Nicole C. Thomas, Xiaolun Wang, Laura Waters, Matthew A. Marx

    Publicado 2022
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  5. 5
    Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

    Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction por John M. Ketcham, Jacob R. Haling, Shilpi Khare, Vickie Bowcut, David M. Briere, Aaron C. Burns, Robin J. Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J. David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbæk, Barbara Saechao, Christopher R. Smith, Niranjan Sudhakar, Nicole C. Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G. Christensen, Matthew A. Marx

    Publicado 2022
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  6. 6
    Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS<sup>G12D</sup> Inhibitor

    Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS<sup>G12D</sup> Inhibitor por Xiaolun Wang, Shelley Allen, James F. Blake, Vickie Bowcut, David M. Briere, Andrew Calinisan, Joshua R. Dahlke, Jay B. Fell, John P. Fischer, Robin J. Gunn, Jill Hallin, Jade Laguer, J. David Lawson, James Medwid, Brad Newhouse, Phong Nguyen, Jacob M. O’Leary, Peter Olson, Spencer Pajk, Lisa Rahbæk, Mareli Rodriguez, Christopher R. Smith, Tony P. Tang, Nicole C. Thomas, Darin Vanderpool, Guy Vigers, James G. Christensen, Matthew A. Marx

    Publicado 2021
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  7. 7
    Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

    Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor por Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella T. Lifset, David Huy Trinh, Natalie Hoffman, Xiaolun Wang, J. David Lawson, Robin J. Gunn, Christopher R. Smith, Nicole C. Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon L. Winski, Leo He, Julio Fernandez-Banet, Adam Pavlı́ček, Jacob R. Haling, Lisa Rahbæk, Matthew A. Marx, Peter Olson, James G. Christensen

    Publicado 2022
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  8. 8
    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <i>MTAP</i>-Deleted Cancer

    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <i>MTAP</i>-Deleted Cancer por Lars D. Engstrom, Ruth Aranda, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, David Trinh, Allan Hebbert, Christopher R. Smith, Svitlana Kulyk, J. David Lawson, Leo He, Laura D. Hover, Julio Fernandez-Banet, Jill Hallin, Darin Vanderpool, David M. Briere, Alice Blaj, Matthew A. Marx, Jordi Rodón, Michael Offin, Kathryn C. Arbour, Melissa L. Johnson, David J. Kwiatkowski, Pasi A. Jänne, Candace L. Haddox, Kyriakos P. Papadopoulos, Jason T. Henry, Konstantinos Leventakos, James G. Christensen, Ronald Shazer, Peter Olson

    Publicado 2023
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  9. 9
    The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

    The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading por Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D. Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M. Ketcham, Anthony Ivetac, Christopher R. Smith, J. David Lawson, Lisa Rahbæk, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, A. J. ELLIOTT, Darin Vanderpool, Leo He, Laura D. Hover, Julio Fernandez-Banet, Sílvia Coma, Jonathan A. Pachter, Jill Hallin, Matthew A. Marx, David M. Briere, James G. Christensen, Peter Olson, Jacob R. Haling, Shilpi Khare

    Publicado 2024
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  10. 10
    Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer

    Acquired Resistance to KRAS<sup>G12C</sup> Inhibition in Cancer por Mark M. Awad, Shengwu Liu, Igor I. Rybkin, Kathryn C. Arbour, Julien Dilly, Viola W. Zhu, Melissa L. Johnson, Rebecca S. Heist, Tejas Patil, Gregory J. Riely, Joseph O. Jacobson, Xiaoping Yang, Nicole S. Persky, David E. Root, Kristen E. Lowder, Hanrong Feng, Shannon Zhang, Kevin M. Haigis, Yin P. Hung, Lynette M. Sholl, Brian M. Wolpin, Julie Wiese, Jason Christiansen, Jessica Lee, Alexa B. Schrock, Lee P. Lim, Kavita Garg, Mark Li, Lars D. Engstrom, Laura Waters, J. David Lawson, Peter Olson, Piro Lito, Sai‐Hong Ignatius Ou, James G. Christensen, Pasi A. Jänne, Andrew J. Aguirre

    Publicado 2021
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