Search Results - Fabrizio Giordanetto

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  1. 1
    Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7

    Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7 by Fabrizio Giordanetto, Romano T. Kroemer

    Published 2002
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  2. 2
    Targeting HSP70 for Cancer Therapy

    Targeting HSP70 for Cancer Therapy by Lorenzo Galluzzi, Fabrizio Giordanetto, Guido Kroemer

    Published 2009
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  3. 3
    Stabilization of protein–protein interactions by small molecules

    Stabilization of protein–protein interactions by small molecules by Fabrizio Giordanetto, Anja Schäfer, Christian Ottmann

    Published 2014
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  4. 4
    Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry

    Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry by Fabrizio Giordanetto, Christian Tyrchan, Johan Ulander

    Published 2017
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    Editorial
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  5. 5
    Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

    Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates by B.C. Doak, Björn Over, Fabrizio Giordanetto, Jan Kihlberg

    Published 2014
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  6. 6
    Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography

    Discovery and Validation of the Binding Poses of Allosteric Fragment Hits to Protein Tyrosine Phosphatase 1b: From Molecular Dynamics Simulations to X-ray Crystallography by Jack B. Greisman, Lindsay Willmore, Christine Y. Yeh, Fabrizio Giordanetto, Sahar Shahamadtar, Hunter Nisonoff, Paul Maragakis, David E. Shaw

    Published 2023
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    Carta
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  7. 7
    Molecular Basis of Small-Molecule Binding to α-Synuclein

    Molecular Basis of Small-Molecule Binding to α-Synuclein by Paul Robustelli, Alain Ibanez-de-Opakua, Cecily K. Campbell-Bezat, Fabrizio Giordanetto, Stefan Becker, Markus Zweckstetter, Albert C. Pan, David E. Shaw

    Published 2022
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  8. 8
    Structural basis of AMPK regulation by small molecule activators

    Structural basis of AMPK regulation by small molecule activators by Bing Xiao, Matthew J. Sanders, David Carmena, Nicola J. Bright, L.F. Haire, E. Underwood, Bhakti Patel, Richard Heath, P.A. Walker, Stefan Hallén, Fabrizio Giordanetto, Stephen R. Martin, David Carling, S.J. Gamblin

    Published 2013
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  9. 9
    Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties

    Impact of Stereospecific Intramolecular Hydrogen Bonding on Cell Permeability and Physicochemical Properties by Björn Over, Patrick McCarren, Per Artursson, Michael A. Foley, Fabrizio Giordanetto, Gunnar Grönberg, Constanze Hilgendorf, Maurice D. Lee, Pär Matsson, Giovanni Muncipinto, Mélanie Pellisson, Matthew W. D. Perry, Richard Svensson, Jeremy R. Duvall, Jan Kihlberg

    Published 2014
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  10. 10
    Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2

    Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2 by Heike Schönherr, Pelin Ayaz, Alexander M. Taylor, Jessica B. Casaletto, B. Barry Touré, Demetri T. Moustakas, Brandi M. Hudson, Roberto Valverde, Songping Zhao, Patrick J. O’Hearn, Lindsey Foster, Dina A. Sharon, Samuel E. Garfinkle, Fabrizio Giordanetto, André Lescarbeau, Ravi Kurukulasuriya, Nastaran Gerami-Moayed, Dejan Maglic, Kamil Bruderek, Gaauri Naik, Hakan Günaydin, Mary M. Mader, Alessandro A. Boezio, Thomas H. McLean, Rongfeng Chen, Yanxia Wang, David E. Shaw, James Watters, Donald A. Bergstrom

    Published 2024
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  11. 11
    Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia

    Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia by Andreas Varkaris, Ermira Pazolli, Hakan Günaydin, Qi Wang, Levi Pierce, Alessandro A. Boezio, Artemisa Bulku, Lucian DiPietro, Cary Fridrich, Adam Frost, Fabrizio Giordanetto, Erika Hamilton, Katherine Harris, Michael Holliday, Tamieka L. Hunter, Amanda Iskandar, Yongli Ji, Alexandre Larivée, Jonathan R. LaRochelle, André Lescarbeau, Fabien Llambi, Brenda Lormil, Mary M. Mader, Brenton G. Mar, Iain Martin, Thomas H. McLean, Klaus Michelsen, Yakov Pechersky, Erika Puente-Poushnejad, Kevin Raynor, Dipali Rogala, Ramin Samadani, Alison M. Schram, Kelley Shortsleeves, Sweta Swaminathan, Shahein Tajmir, Gege Tan, Yong Tang, Roberto Valverde, Bryan Wehrenberg, Jeremy Wilbur, Bret R. Williams, Hongtao Zeng, Hanmo Zhang, W. Patrick Walters, Beni B. Wolf, David E. Shaw, Donald A. Bergstrom, James Watters, James S. Fraser, Pascal D. Fortin, D. Randal Kipp

    Published 2023
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