Výsledky vyhledávání - Barbara Saechao

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  1. 1
    Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A

    Combination therapy of adagrasib and abemaciclib in non-small cell lung cancer brain metastasis models genomically characterized by KRAS-G12C and homozygous loss of CDKN2A Autor Christian Migliarese, Yinon Sadeh, Consuelo Torrini, Fatma Turna Demir, Naema Nayyar, Erika Yamazawa, Y. Ishikawa, Nazanin Ijad, Elizabeth J Summers, Adam Elliott, Lisa Rahbæk, Barbara Saechao, Jill Hallin, Priscilla K. Brastianos, Hiroaki Wakimoto

    Vydáno 2025
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  2. 2
    Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction

    Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein–Protein Interaction Autor John M. Ketcham, Jacob R. Haling, Shilpi Khare, Vickie Bowcut, David M. Briere, Aaron C. Burns, Robin J. Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J. David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbæk, Barbara Saechao, Christopher R. Smith, Niranjan Sudhakar, Nicole C. Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G. Christensen, Matthew A. Marx

    Vydáno 2022
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  3. 3
    The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading

    The SOS1 Inhibitor MRTX0902 Blocks KRAS Activation and Demonstrates Antitumor Activity in Cancers Dependent on KRAS Nucleotide Loading Autor Niranjan Sudhakar, Larry Yan, Fadia Qiryaqos, Lars D. Engstrom, Jade Laguer, Andrew Calinisan, Allan Hebbert, Laura Waters, Krystal Moya, Vickie Bowcut, Laura Vegar, John M. Ketcham, Anthony Ivetac, Christopher R. Smith, J. David Lawson, Lisa Rahbæk, Jeffrey Clarine, Natalie Nguyen, Barbara Saechao, Cody Parker, A. J. ELLIOTT, Darin Vanderpool, Leo He, Laura D. Hover, Julio Fernandez-Banet, Sílvia Coma, Jonathan A. Pachter, Jill Hallin, Matthew A. Marx, David M. Briere, James G. Christensen, Peter Olson, Jacob R. Haling, Shilpi Khare

    Vydáno 2024
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