eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury

eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury

Background: Numerous potential ARDS therapeutics, based upon preclinical successful rodent studies that utilized LPS challenge without mechanical ventilation, have failed in Phase 2/3 clinical trials. Recently, ALT-100 mAb, a novel biologic that neutralizes the TLR4 ligand and DAMP, eNAMPT (extracel...

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Detaylı Bibliyografya
Asıl Yazarlar: Sammani, Saad, Bermudez, Tadeo, Kempf, Carrie L., Song, Jin H., Fleming, Justin C, Reyes Hernon, Vivian, Hufford, Matthew, Tang, Lin, Cai, Hua, Camp, Sara M., Natarajan, Viswanathan, Jacobson, Jeffrey R., Dudek, Steven M., Martin, Diego R., Karmonik, Christof, Sun, Xiaoguang, Sun, Belinda, Casanova, Nancy G., Bime, Christian, Garcia, Joe G. N.
Materyal Türü: Metin
Dil:İngilizce
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2022
Konular:
Physiology
Online Erişim:https://pmc.ncbi.nlm.nih.gov/articles/PMC9257134/
https://pubmed.ncbi.nlm.nih.gov/35812318
http://dx.doi.org/10.3389/fphys.2022.916159
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Internet

https://pmc.ncbi.nlm.nih.gov/articles/PMC9257134/
https://pubmed.ncbi.nlm.nih.gov/35812318
http://dx.doi.org/10.3389/fphys.2022.916159

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