Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program

While polygenic risk scores (PRSs) enable early identification of genetic risk for chronic obstructive pulmonary disease (COPD), predictive performance is limited when the discovery and target populations are not well matched. Hypothesizing that the biological mechanisms of disease are shared across...

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Main Authors: Hu, Xiaowei, Qiao, Dandi, Kim, Wonji, Moll, Matthew, Balte, Pallavi P., Lange, Leslie A., Bartz, Traci M., Kumar, Rajesh, Li, Xingnan, Yu, Bing, Cade, Brian E., Laurie, Cecelia A., Sofer, Tamar, Ruczinski, Ingo, Nickerson, Deborah A., Muzny, Donna M., Metcalf, Ginger A., Doddapaneni, Harshavardhan, Gabriel, Stacy, Gupta, Namrata, Dugan-Perez, Shannon, Cupples, L. Adrienne, Loehr, Laura R., Jain, Deepti, Rotter, Jerome I., Wilson, James G., Psaty, Bruce M., Fornage, Myriam, Morrison, Alanna C., Vasan, Ramachandran S., Washko, George, Rich, Stephen S., O’Connor, George T., Bleecker, Eugene, Kaplan, Robert C., Kalhan, Ravi, Redline, Susan, Gharib, Sina A., Meyers, Deborah, Ortega, Victor, Dupuis, Josée, London, Stephanie J., Lappalainen, Tuuli, Oelsner, Elizabeth C., Silverman, Edwin K., Barr, R. Graham, Thornton, Timothy A., Wheeler, Heather E., Cho, Michael H., Im, Hae Kyung, Manichaikul, Ani
Format: Text
Language:English
Published: Elsevier 2022
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC9118106/
https://pubmed.ncbi.nlm.nih.gov/35385699
http://dx.doi.org/10.1016/j.ajhg.2022.03.007
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https://pmc.ncbi.nlm.nih.gov/articles/PMC9118106/
https://pubmed.ncbi.nlm.nih.gov/35385699
http://dx.doi.org/10.1016/j.ajhg.2022.03.007

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