Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization

Involvement of eNAMPT/TLR4 signaling in murine radiation pneumonitis: protection by eNAMPT neutralization

Therapeutic strategies to prevent or reduce the severity of radiation pneumonitis are a serious unmet need. We evaluated extracellular nicotinamide phosphoribosyltransferase (eNAMPT), a damage-associated molecular pattern protein (DAMP) and Toll-Like Receptor 4 (TLR4) ligand, as a therapeutic target...

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Main Authors: Garcia, Alexander N., Casanova, Nancy G., Valera, Daniel G., Sun, Xiaoguang, Song, Jin H., Kempf, Carrie L., Moreno-Vinasco, Liliana, Burns, Kimberlie, Bermudez, Tadeo, Valdez, Mia, Cuellar, Genesis, Gregory, Taylor, Oita, Radu C., Hernon, Vivian Reyes, Barber, Christy, Camp, Sara M., Martin, Diego, Liu, Zhonglin, Bime, Christian, Sammani, Saad, Cress, Anne E., Garcia, Joe GN
Format: Text
Language:English
Published: 2021
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671169/
https://pubmed.ncbi.nlm.nih.gov/34139379
http://dx.doi.org/10.1016/j.trsl.2021.06.002
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https://pmc.ncbi.nlm.nih.gov/articles/PMC8671169/
https://pubmed.ncbi.nlm.nih.gov/34139379
http://dx.doi.org/10.1016/j.trsl.2021.06.002

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