Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia

Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia

BACKGROUND: Diminished synaptic gain—the sensitivity of postsynaptic responses to neural inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or interneurons (or both) are affected, or how these de...

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Main Authors: Adams, Rick A., Pinotsis, Dimitris, Tsirlis, Konstantinos, Unruh, Leonhardt, Mahajan, Aashna, Horas, Ana Montero, Convertino, Laura, Summerfelt, Ann, Sampath, Hemalatha, Du, Xiaoming Michael, Kochunov, Peter, Ji, Jie Lisa, Repovs, Grega, Murray, John D., Friston, Karl J., Hong, L. Elliot, Anticevic, Alan
Format: Text
Language:English
Published: Elsevier 2022
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC8654393/
https://pubmed.ncbi.nlm.nih.gov/34598786
http://dx.doi.org/10.1016/j.biopsych.2021.07.024
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https://pmc.ncbi.nlm.nih.gov/articles/PMC8654393/
https://pubmed.ncbi.nlm.nih.gov/34598786
http://dx.doi.org/10.1016/j.biopsych.2021.07.024

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