Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Endothelial eNAMPT drives EndMT and preclinical PH: rescue by an eNAMPT-neutralizing mAb

Pharmacologic interventions to halt/reverse the vascular remodeling and right ventricular dysfunction in pulmonary arterial hypertension (PAH) remains an unmet need. We previously demonstrated extracellular nicotinamide phosphoribosyltransferase (eNAMPT) as a DAMP (damage-associated molecular patter...

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Main Authors: Ahmed, Mohamed, Zaghloul, Nahla, Zimmerman, Prisca, Casanova, Nancy G., Sun, Xiaoguang, Song, Jin H., Hernon, Vivian Reyes, Sammani, Saad, Rischard, Franz, Rafikova, Olga, Rafikov, Ruslan, Makino, Ayako, Kempf, Carrie L., Camp, Sara M., Wang, Jian, Desai, Ankit A., Lussier, Yves, Yuan, Jason X.-J., Garcia, Joe G.N.
Format: Text
Language:English
Published: SAGE Publications 2021
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Original Research Article
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC8591779/
https://pubmed.ncbi.nlm.nih.gov/34790349
http://dx.doi.org/10.1177/20458940211059712
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https://pmc.ncbi.nlm.nih.gov/articles/PMC8591779/
https://pubmed.ncbi.nlm.nih.gov/34790349
http://dx.doi.org/10.1177/20458940211059712

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