One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency

One Gene, Many Facets: Multiple Immune Pathway Dysregulation in SOCS1 Haploinsufficiency

BACKGROUND: Inborn errors of immunity (IEI) present with a large phenotypic spectrum of disease, which can pose diagnostic and therapeutic challenges. Suppressor of cytokine signaling 1 (SOCS1) is a key negative regulator of cytokine signaling, and has recently been associated with a novel IEI. Of p...

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Main Authors: Körholz, Julia, Gabrielyan, Anastasia, Sowerby, John M., Boschann, Felix, Chen, Lan-Sun, Paul, Diana, Brandt, David, Kleymann, Janina, Kolditz, Martin, Toepfner, Nicole, Knöfler, Ralf, Jacobsen, Eva-Maria, Wolf, Christine, Conrad, Karsten, Röber, Nadja, Lee-Kirsch, Min Ae, Smith, Kenneth G. C., Mundlos, Stefan, Berner, Reinhard, Dalpke, Alexander H., Schuetz, Catharina, Rae, William
Format: Text
Language:English
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC8375263/
https://pubmed.ncbi.nlm.nih.gov/34421895
http://dx.doi.org/10.3389/fimmu.2021.680334
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https://pmc.ncbi.nlm.nih.gov/articles/PMC8375263/
https://pubmed.ncbi.nlm.nih.gov/34421895
http://dx.doi.org/10.3389/fimmu.2021.680334

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