Balance Between Rapid Delayed Rectifier K(+) Current and Late Na(+) Current on Ventricular Repolarization: An Effective Antiarrhythmic Target?

Balance Between Rapid Delayed Rectifier K(+) Current and Late Na(+) Current on Ventricular Repolarization: An Effective Antiarrhythmic Target?

BACKGROUND: Rapid delayed rectifier K(+) current (I(Kr)) and late Na(+) current (I(NaL)) significantly shape the cardiac action potential (AP). Changes in their magnitudes can cause either long or short QT syndromes (LQT, SQT) associated with malignant ventricular arrhythmias and sudden cardiac deat...

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Main Authors: Hegyi, Bence, Chen-Izu, Ye, Izu, Leighton T., Rajamani, Sridharan, Belardinelli, Luiz, Bers, Donald M., Bányász, Tamás
Format: Text
Language:English
Published: 2020
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC7331791/
https://pubmed.ncbi.nlm.nih.gov/32202931
http://dx.doi.org/10.1161/CIRCEP.119.008130
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https://pmc.ncbi.nlm.nih.gov/articles/PMC7331791/
https://pubmed.ncbi.nlm.nih.gov/32202931
http://dx.doi.org/10.1161/CIRCEP.119.008130

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