MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

MicroRNA-140 is elevated and mitofusin-1 is downregulated in the right ventricle of the Sugen5416/hypoxia/normoxia model of pulmonary arterial hypertension.

Heart failure, a major cause of morbidity and mortality in patients with pulmonary arterial hypertension (PAH), is an outcome of complex biochemical processes. In this study, we determined changes in microRNAs (miRs) in the right and left ventricles of normal and PAH rats. Using an unbiased quantita...

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Bibliographic Details
Main Authors: Joshi, Sachindra Raj, Dhagia, Vidhi, Gairhe, Salina, Edwards, John G., McMurtry, Ivan F., Gupte, Sachin A.
Format: Text
Language:English
Published: American Physiological Society 2016
Subjects:
Integrative Cardiovascular Physiology and Pathophysiology
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC7199238/
https://pubmed.ncbi.nlm.nih.gov/27422986
http://dx.doi.org/10.1152/ajpheart.00264.2016
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https://pmc.ncbi.nlm.nih.gov/articles/PMC7199238/
https://pubmed.ncbi.nlm.nih.gov/27422986
http://dx.doi.org/10.1152/ajpheart.00264.2016

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