Genome-wide cell-free DNA fragmentation in patients with cancer

Genome-wide cell-free DNA fragmentation in patients with cancer

Cell-free DNA (cfDNA) in the blood provides a noninvasive diagnostic avenue for patients with cancer(1). However, characteristics of the origins and molecular features of cfDNA are poorly understood. We developed an approach to evaluate fragmentation patterns of cfDNA across the genome and found tha...

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Main Authors: Cristiano, Stephen, Leal, Alessandro, Phallen, Jillian, Fiksel, Jacob, Adleff, Vilmos, Bruhm, Daniel C., Jensen, Sarah Østrup, Medina, Jamie E., Hruban, Carolyn, White, James R., Palsgrove, Doreen N., Niknafs, Noushin, Anagnostou, Valsamo, Forde, Patrick, Naidoo, Jarushka, Marrone, Kristen, Brahmer, Julie, Woodward, Brian D., Husain, Hatim, van Rooijen, Karlijn L., Ørntoft, Mai-Britt Worm, Madsen, Anders Husted, van de Velde, Cornelis J.H., Verheij, Marcel, Cats, Annemieke, Punt, Cornelis J.A., Vink, Geraldine R., van Grieken, Nicole C.T., Koopman, Miriam, Fijneman, Remond J.A., Johansen, Julia S., Nielsen, Hans Jørgen, Meijer, Gerrit A., Andersen, Claus Lindbjerg, Scharpf, Robert B., Velculescu, Victor E.
Format: Text
Language:English
Published: 2019
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC6774252/
https://pubmed.ncbi.nlm.nih.gov/31142840
http://dx.doi.org/10.1038/s41586-019-1272-6
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https://pmc.ncbi.nlm.nih.gov/articles/PMC6774252/
https://pubmed.ncbi.nlm.nih.gov/31142840
http://dx.doi.org/10.1038/s41586-019-1272-6

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