Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading

Treatment With a Soluble Bone Morphogenetic Protein Type 1A Receptor (BMPR1A) Fusion Protein Increases Bone Mass and Bone Formation in Mice Subjected to Hindlimb Unloading

Previous work has shown that the soluble murine BMPR1A–fusion protein (mBMPR1A‐mFc) binds to BMP2 and BMP4 with high affinity, preventing downstream signaling. Further, treatment of intact and ovariectomized mice with mBMPR1A‐mFc leads to increased bone mass, and improved bone microarchitecture and...

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Main Authors: Ko, Frank C., Van Vliet, Miranda, Ellman, Rachel, Grasso, Daniel, Brooks, Daniel J, Spatz, Jordan M, Conlon, Chrissy, Aguirre, J Ignacio, Wronski, Thomas J, Bouxsein, Mary L
Format: Text
Language:English
Published: John Wiley and Sons Inc. 2017
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Original Articles
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC6124165/
https://pubmed.ncbi.nlm.nih.gov/30283882
http://dx.doi.org/10.1002/jbm4.10012
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https://pmc.ncbi.nlm.nih.gov/articles/PMC6124165/
https://pubmed.ncbi.nlm.nih.gov/30283882
http://dx.doi.org/10.1002/jbm4.10012

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