Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy

Potentiating the effects of radiotherapy in rectal cancer: the role of aspirin, statins and metformin as adjuncts to therapy

BACKGROUND: Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20–30% of patients. Drug repurposing for anti-cancer treatments is gaining moment...

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Bibliographic Details
Main Authors: Gash, K J, Chambers, A C, Cotton, D E, Williams, A C, Thomas, M G
Format: Text
Language:English
Published: Nature Publishing Group 2017
Subjects:
Translational Therapeutics
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC5520519/
https://pubmed.ncbi.nlm.nih.gov/28641310
http://dx.doi.org/10.1038/bjc.2017.175
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5520519/
https://pubmed.ncbi.nlm.nih.gov/28641310
http://dx.doi.org/10.1038/bjc.2017.175

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