Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

Bcl-3 is an atypical NF-κB family member that regulates NF-κB-dependent gene expression in effector T cells, but a cell-intrinsic function in regulatory T (Treg) cells and colitis is not clear. Here we show that Bcl-3 expression levels in colonic T cells correlate with disease manifestation in patie...

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Main Authors: Reißig, Sonja, Tang, Yilang, Nikolaev, Alexei, Gerlach, Katharina, Wolf, Christine, Davari, Kathrin, Gallus, Christian, Masri, Joumana, Mufazalov, Ilgiz A., Neurath, Markus F., Wunderlich, F. Thomas, Schattenberg, Jörn M., Galle, Peter R., Weigmann, Benno, Waisman, Ari, Glasmacher, Elke, Hövelmeyer, Nadine
Format: Text
Language:English
Published: Nature Publishing Group 2017
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC5414353/
https://pubmed.ncbi.nlm.nih.gov/28452361
http://dx.doi.org/10.1038/ncomms15069
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https://pmc.ncbi.nlm.nih.gov/articles/PMC5414353/
https://pubmed.ncbi.nlm.nih.gov/28452361
http://dx.doi.org/10.1038/ncomms15069

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