SAMHD1 prevents autoimmunity by maintaining genome stability

SAMHD1 prevents autoimmunity by maintaining genome stability

OBJECTIVES: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi–Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity wit...

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Main Authors: Kretschmer, Stefanie, Wolf, Christine, König, Nadja, Staroske, Wolfgang, Guck, Jochen, Häusler, Martin, Luksch, Hella, Nguyen, Laura A, Kim, Baek, Alexopoulou, Dimitra, Dahl, Andreas, Rapp, Alexander, Cardoso, M Cristina, Shevchenko, Anna, Lee-Kirsch, Min Ae
Format: Text
Language:English
Published: BMJ Publishing Group 2015
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC4345975/
https://pubmed.ncbi.nlm.nih.gov/24445253
http://dx.doi.org/10.1136/annrheumdis-2013-204845
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https://pmc.ncbi.nlm.nih.gov/articles/PMC4345975/
https://pubmed.ncbi.nlm.nih.gov/24445253
http://dx.doi.org/10.1136/annrheumdis-2013-204845

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