The Hypoxic Response Contributes to Altered Gene Expression and Pre-Capillary Pulmonary Hypertension in Patients with Sickle Cell Disease

The Hypoxic Response Contributes to Altered Gene Expression and Pre-Capillary Pulmonary Hypertension in Patients with Sickle Cell Disease

BACKGROUND: We postulated that the hypoxic response in sickle cell disease (SCD) contributes to altered gene expression and pulmonary hypertension, a complication associated with early mortality. METHODS AND RESULTS: To identify genes regulated by the hypoxic response and not other effects of chroni...

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Main Authors: Zhang, Xu, Zhang, Wei, Ma, Shwu-Fan, Desai, Ankit A., Saraf, Santosh, Miasniakova, Galina, Sergueeva, Adelina, Ammosova, Tatiana, Xu, Min, Nekhai, Sergei, Abbasi, Taimur, Casanova, Nancy G., Steinberg, Martin H., Baldwin, Clinton T., Sebastiani, Paola, Prchal, Josef T., Kittles, Rick, Garcia, Joe G. N., Machado, Roberto F., Gordeuk, Victor R.
Format: Text
Language:English
Published: 2014
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC4287376/
https://pubmed.ncbi.nlm.nih.gov/24515990
http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005296
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https://pmc.ncbi.nlm.nih.gov/articles/PMC4287376/
https://pubmed.ncbi.nlm.nih.gov/24515990
http://dx.doi.org/10.1161/CIRCULATIONAHA.113.005296

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