Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength. Heterozygous missense mutations in LRP5 cause autosomal dominant high bone mass (HBM) in humans by reducing binding to LRP5 by endogenous inhibitors, such as scleros...

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Hlavní autoři: Jacobsen, Christina M., Barber, Lauren A., Ayturk, Ugur M., Roberts, Heather J., Deal, Lauren E., Schwartz, Marissa A., Weis, MaryAnn, Eyre, David, Zurakowski, David, Robling, Alexander G., Warman, Matthew L.
Médium: Text
Jazyk:angličtina
Vydáno: 2014
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Article
On-line přístup:https://pmc.ncbi.nlm.nih.gov/articles/PMC4130796/
https://pubmed.ncbi.nlm.nih.gov/24677211
http://dx.doi.org/10.1002/jbmr.2198
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Internet

https://pmc.ncbi.nlm.nih.gov/articles/PMC4130796/
https://pubmed.ncbi.nlm.nih.gov/24677211
http://dx.doi.org/10.1002/jbmr.2198

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