Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

Targeting the LRP5 pathway improves bone properties in a mouse model of Osteogenesis Imperfecta

The cell surface receptor low-density lipoprotein receptor-related protein 5 (LRP5) is a key regulator of bone mass and bone strength. Heterozygous missense mutations in LRP5 cause autosomal dominant high bone mass (HBM) in humans by reducing binding to LRP5 by endogenous inhibitors, such as scleros...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jacobsen, Christina M., Barber, Lauren A., Ayturk, Ugur M., Roberts, Heather J., Deal, Lauren E., Schwartz, Marissa A., Weis, MaryAnn, Eyre, David, Zurakowski, David, Robling, Alexander G., Warman, Matthew L.
Fformat: Text
Iaith:Saesneg
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://pmc.ncbi.nlm.nih.gov/articles/PMC4130796/
https://pubmed.ncbi.nlm.nih.gov/24677211
http://dx.doi.org/10.1002/jbmr.2198
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https://pmc.ncbi.nlm.nih.gov/articles/PMC4130796/
https://pubmed.ncbi.nlm.nih.gov/24677211
http://dx.doi.org/10.1002/jbmr.2198

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