Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell-line genomic analyses

Identification of genetic variants associated with capecitabine-induced hand-foot syndrome through integration of patient and cell-line genomic analyses

OBJECTIVE: A primary challenge in identifying replicable pharmacogenomic markers from clinical genome wide association study (GWAS) trials in oncology is the difficulty of performing a second large clinical trial with the same drugs and dosage regimen. We sought to overcome this challenge by incorpo...

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Main Authors: Wheeler, Heather E., Gonzalez-Neira, Anna, Pita, Guillermo, de la Torre- Montero, Julio-Cesar, Alonso, Rosario, Lopez-Fernandez, Luis A., Alba, Emilio, Martín, Miguel, Dolan, M. Eileen
Format: Text
Language:English
Published: 2014
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC4076106/
https://pubmed.ncbi.nlm.nih.gov/24595012
http://dx.doi.org/10.1097/FPC.0000000000000037
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https://pmc.ncbi.nlm.nih.gov/articles/PMC4076106/
https://pubmed.ncbi.nlm.nih.gov/24595012
http://dx.doi.org/10.1097/FPC.0000000000000037

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