Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

Sclerostin Inhibition Reverses Skeletal Fragility in an Lrp5-Deficient Mouse Model of OPPG Syndrome

Osteoporosis pseudoglioma syndrome (OPPG) is a rare genetic disease that produces debilitating effects in the skeleton. OPPG is caused by mutations in LRP5, a WNT co-receptor that mediates osteoblast activity. WNT signaling through LRP5, and also through the closely related receptor LRP6, is inhibit...

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Main Authors: Kedlaya, Rajendra, Veera, Shreya, Horan, Daniel J., Moss, Rachel E., Ayturk, Ugur M., Jacobsen, Christina M., Bowen, Margot E., Paszty, Chris, Warman, Matthew L., Robling, Alexander G.
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Language:English
Published: 2013
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC3964772/
https://pubmed.ncbi.nlm.nih.gov/24225945
http://dx.doi.org/10.1126/scitranslmed.3006627
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3964772/
https://pubmed.ncbi.nlm.nih.gov/24225945
http://dx.doi.org/10.1126/scitranslmed.3006627

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