Guanine Nucleotide Exchange Factors (GEFs) Have a Critical but Not Exclusive Role in Organelle Localization of Rab GTPases
Membrane fusion at eukaryotic organelles is initiated by Rab GTPases and tethering factors. Rabs in their GDP-bound form are kept soluble in the cytoplasm by the GDP dissociation inhibitor (GDI) chaperone. Guanine nucleotide exchange factors (GEFs) are found at organelles and are critical for Rab fu...
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| Main Authors: | , |
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| Format: | Text |
| Language: | English |
| Published: |
American Society for Biochemistry and Molecular Biology
2013
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| Subjects: | |
| Online Access: | https://pmc.ncbi.nlm.nih.gov/articles/PMC3789967/ https://pubmed.ncbi.nlm.nih.gov/23979137 http://dx.doi.org/10.1074/jbc.M113.488213 |
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