Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit

Intranuclear delivery of a novel antibody-derived radiosensitizer targeting the DNA-dependent protein kinase catalytic subunit

PURPOSE: To inhibit DNA double-strand break repair in tumor cells by delivery of a single chain antibody variable region fragment (ScFv 18-2) to the cell nucleus. ScFv 18-2 binds to a regulatory region of the DNA-dependent protein kinase (DNA-PK), an essential enzyme in the nonhomologous end-joining...

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Main Authors: Xiong, Hairong, Lee, Robert J., Haura, Eric B., Edwards, John G., Dynan, William S., Li, Shuyi
Format: Text
Language:English
Published: 2011
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC3698569/
https://pubmed.ncbi.nlm.nih.gov/22138455
http://dx.doi.org/10.1016/j.ijrobp.2011.08.039
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3698569/
https://pubmed.ncbi.nlm.nih.gov/22138455
http://dx.doi.org/10.1016/j.ijrobp.2011.08.039

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