An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells

An Integrated Expression Profiling Reveals Target Genes of TGF-β and TNF-α Possibly Mediated by MicroRNAs in Lung Cancer Cells

EMT (epithelial-mesenchymal transition) is crucial for cancer cells to acquire invasive phenotypes. In A549 lung adenocarcinoma cells, TGF-β elicited EMT in Smad-dependent manner and TNF-α accelerated this process, as confirmed by cell morphology, expression of EMT markers, capacity of gelatin lysis...

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Bibliographic Details
Main Authors: Saito, Akira, Suzuki, Hiroshi I., Horie, Masafumi, Ohshima, Mitsuhiro, Morishita, Yasuyuki, Abiko, Yoshimitsu, Nagase, Takahide
Format: Text
Language:English
Published: Public Library of Science 2013
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Research Article
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC3577886/
https://pubmed.ncbi.nlm.nih.gov/23437179
http://dx.doi.org/10.1371/journal.pone.0056587
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3577886/
https://pubmed.ncbi.nlm.nih.gov/23437179
http://dx.doi.org/10.1371/journal.pone.0056587

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