ACTN3 Allele Frequency in Humans Covaries with Global Latitudinal Gradient

A premature stop codon in ACTN3 resulting in α-actinin-3 deficiency (the ACTN3 577XX genotype) is common in humans and reduces strength, muscle mass, and fast-twitch fiber diameter, but increases the metabolic efficiency of skeletal muscle. Linkage disequilibrium data suggest that the ACTN3 R577X al...

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Bibliographic Details
Main Authors: Friedlander, Scott M., Herrmann, Amanda L., Lowry, Daniel P., Mepham, Emily R., Lek, Monkol, North, Kathryn N., Organ, Chris L.
Format: Text
Language:English
Published: Public Library of Science 2013
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC3554748/
https://pubmed.ncbi.nlm.nih.gov/23359641
http://dx.doi.org/10.1371/journal.pone.0052282
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