Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Mutations in the renal tumour suppressor protein, folliculin, lead to proliferative skin lesions, lung complications and renal cell carcinoma. Folliculin has been reported to interact with AMP-activated kinase, a key component of the mammalian target of rapamycin pathway. Most cancer-causing mutatio...

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Main Authors: Nookala, Ravi K., Langemeyer, Lars, Pacitto, Angela, Ochoa-Montaño, Bernardo, Donaldson, Jane C., Blaszczyk, Beata K., Chirgadze, Dimitri Y., Barr, Francis A., Bazan, J. Fernando, Blundell, Tom L.
Format: Text
Language:English
Published: The Royal Society 2012
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Research
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC3438538/
https://pubmed.ncbi.nlm.nih.gov/22977732
http://dx.doi.org/10.1098/rsob.120071
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3438538/
https://pubmed.ncbi.nlm.nih.gov/22977732
http://dx.doi.org/10.1098/rsob.120071

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