Intercalative binding to DNA of antitumour drugs derived from 3-nitro-1,8-naphthalic acid.
Two new antitumour drugs, imide derivatives of 3-nitro-1,8-naphthalic acid having different basic side chains linked to the imide nitrogen, have been shown to bind to double-helical DNA by intercalation. At ionic strength 0.01 mol/litre, pH 7, their intrinsic association constants are about 1.45 x 1...
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| Main Authors: | , , , |
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| Format: | Text |
| Language: | English |
| Published: |
1979
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| Online Access: | https://pmc.ncbi.nlm.nih.gov/articles/PMC328007/ https://pubmed.ncbi.nlm.nih.gov/573892 |
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