Novel MEK1 Mutation Identified by Mutational Analysis of Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma

Novel MEK1 Mutation Identified by Mutational Analysis of Epidermal Growth Factor Receptor Signaling Pathway Genes in Lung Adenocarcinoma

Genetic lesions affecting a number of kinases and other elements within the epidermal growth factor receptor (EGFR) signaling pathway have been implicated in the pathogenesis of human non–small-cell lung cancer (NSCLC). We performed mutational profiling of a large cohort of lung adenocarcinomas to u...

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Main Authors: Marks, Jenifer L., Gong, Yixuan, Chitale, Dhananjay, Golas, Ben, McLellan, Michael D., Kasai, Yumi, Ding, Li, Mardis, Elaine R., Wilson, Richard K., Solit, David, Levine, Ross, Michel, Kathrin, Thomas, Roman K., Rusch, Valerie W., Ladanyi, Marc, Pao, William
Format: Text
Language:English
Published: 2008
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Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC2586155/
https://pubmed.ncbi.nlm.nih.gov/18632602
http://dx.doi.org/10.1158/0008-5472.CAN-08-0099
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https://pmc.ncbi.nlm.nih.gov/articles/PMC2586155/
https://pubmed.ncbi.nlm.nih.gov/18632602
http://dx.doi.org/10.1158/0008-5472.CAN-08-0099

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