Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

Transforming growth factor β targeted inactivation of cyclin E:cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity

Transforming growth factor β (TGF-β)-mediated G(1) arrest previously has been shown to specifically target inactivation of cyclin D:cyclin-dependent kinase (Cdk) 4/6 complexes. We report here that TGF-β-treated human HepG2 hepatocellular carcinoma cells arrest in G(1), but retain continued cyclin D:...

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Bibliographic Details
Main Authors: Nagahara, Hikaru, Ezhevsky, Sergei A., Vocero-Akbani, Adamina M., Kaldis, Philipp, Solomon, Mark J., Dowdy, Steven F.
Format: Text
Language:English
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://pmc.ncbi.nlm.nih.gov/articles/PMC24755/
https://pubmed.ncbi.nlm.nih.gov/10611320
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https://pmc.ncbi.nlm.nih.gov/articles/PMC24755/
https://pubmed.ncbi.nlm.nih.gov/10611320

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