Role of de Novo DNA Methyltransferases and Methyl CpG-binding Proteins in Gene Silencing in a Rat Hepatoma
The expression of metallothionein-I (MT-I), a known antioxidant, was suppressed in a transplanted rat hepatoma because of promoter methylation and was induced by heavy metals only after demethylation by 5-azacytidine (5-AzaC). Treatment of the tumor-bearing rats with 5-AzaC resulted in significant r...
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| Main Authors: | , , , , , , , |
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| Format: | Text |
| Language: | English |
| Published: |
2002
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| Subjects: | |
| Online Access: | https://pmc.ncbi.nlm.nih.gov/articles/PMC2241740/ https://pubmed.ncbi.nlm.nih.gov/11844796 http://dx.doi.org/10.1074/jbc.M111662200 |
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