Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

Abstract In vivo functional investigation of oncogenes using somatic gene transfer has been successfully exploited to validate their role in tumorigenesis. For tumour suppressor genes this has proven more challenging due to technical aspects. To provide a flexible and effective method for investigat...

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Main Authors: Marc Zuckermann, Volker Hovestadt, Christiane B. Knobbe‐Thomsen, Marc Zapatka, Paul A. Northcott, Kathrin Schramm, Jelena Belic, David Jones, Barbara R. Tschida, Branden S. Moriarity, David A. Largaespada, Martine F. Roussel, Andrey Korshunov, Guido Reifenberger, Stefan M. Pfister, Peter Lichter, Daisuke Kawauchi, Jan Gronych
Format: Artigo
Language:English
Published: 2015
Online Access:https://doi.org/10.1038/ncomms8391
https://www.nature.com/articles/ncomms8391.pdf
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https://doi.org/10.1038/ncomms8391
https://www.nature.com/articles/ncomms8391.pdf

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