Efficacy of CDK4/6 Inhibition in colorectal cancer and the role of p16 expression in predicting drug resistance

Efficacy of CDK4/6 Inhibition in colorectal cancer and the role of p16 expression in predicting drug resistance

Abstract Introduction Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. The use of sequential polychemotherapies has improved the survival of patients with advanced metastatic disease. However, the survival rates achieved are low, and chemotherapy-related side effects...

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Hoofdauteurs: Julia Schneider, Najib Ben Khaled, Liangtao Ye, Ralf Wimmer, Linda Hammann, Alexander Weich, Christoph Suppan, Ujjwal Mukund Mahajan, A. W. Jung, Jörg Kumbrink, Gerald Denk, Monika Rau, Volker Kunzmann, Solveig Kuss, Jan Neuman, Julia Mayerle, Andreas Geier, Heike M. Hermanns, Enrico N. De Toni, Florian P. Reiter
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2025
Online toegang:https://doi.org/10.1007/s13402-025-01080-7
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https://doi.org/10.1007/s13402-025-01080-7

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