Interferon-γ orchestrates leptomeningeal anti-tumour response

Interferon-γ orchestrates leptomeningeal anti-tumour response

Metastasis to the cerebrospinal-fluid-filled leptomeninges, or leptomeningeal metastasis, represents a fatal complication of solid tumours1. Multimodal analyses of clinical specimens reveal substantial inflammatory infiltrate in leptomeningeal metastases with enrichment of IFNγ and resulting downstr...

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Main Authors: Ján Remšík, Xinran Tong, Russell Kunes, Minjun Li, Rachel Estrera, Jenna Snyder, Christopher W. Thomson, Ahmed M. Osman, Kiana Chabot, Uğur Sener, Jessica Wilcox, Danielle Isakov, Helen G. Wang, Tejus Bale, Ronan Chaligné, Joseph C. Sun, Chrysothemis C. Brown, Dana Pe’er, Adrienne Boire
Format: Artigo
Sprog:engelsk
Udgivet: 2025
Online adgang:https://doi.org/10.1038/s41586-025-09012-z
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https://doi.org/10.1038/s41586-025-09012-z

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