Cyclic increase in the histamine receptor H1-ADAM9-Snail/Slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma

Abstract The intricate involvement of the histaminergic system, encompassing histamine and histamine receptors, in the progression of diverse neoplasias has attracted considerable scrutiny. Histamine receptor H1 (HRH1) was reported to be overexpressed in several cancer types, but its specific functi...

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Auteurs principaux: Yi‐Fang Ding, Kuo-Hao Ho, Wei‐Jiunn Lee, Li‐Hsin Chen, Feng-Koo Hsieh, Min‐Che Tung, Shu‐Hui Lin, Michael Hsiao, Shun‐Fa Yang, Yi‐Chieh Yang, Ming‐Hsien Chien
Format: Artigo
Langue:anglais
Publié: 2025
Accès en ligne:https://doi.org/10.1038/s41419-025-07507-1
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