A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity

A critical role of N4-acetylation of cytidine in mRNA by NAT10 in T cell expansion and antiviral immunity

Following activation, naive T cells exit quiescence and require global translation for rapid expansion, yet the underlying mechanisms remain unclear. Here, we show that during T cell activation, cells upregulate the expression of N-acetyltransferase 10 (NAT10), an enzyme responsible for N4-acetylcyt...

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Hauptverfasser: Lu Sun, Xiaoyan Li, Feixiang Xu, Yu‐Wen Chen, Xushuo Li, Zhicheng Yang, Ying Yang, Ke Wang, Tianyi Ren, Zihao Lin, Hua Wang, Xiangdong Wang, Yan Lü, Zhenju Song, Zhou‐Li Cheng, Duojiao Wu
Format: Artigo
Sprache:Englisch
Veröffentlicht: 2025
Online-Zugang:https://doi.org/10.1038/s41590-025-02100-2
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https://doi.org/10.1038/s41590-025-02100-2

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