Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects
Despite the various therapeutic benefits and high tolerance of orally administered silybin, poor water-solubility can be the main restrictive physicochemical feature, which results in low oral bioavailability in the absorption. A milk thistle nanocrystal formulation (HM40) was prepared using a modif...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2024
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| Online Access: | https://doi.org/10.3390/pharmaceutics16081033 https://www.mdpi.com/1999-4923/16/8/1033/pdf?version=1722592580 |
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