Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects

Despite the various therapeutic benefits and high tolerance of orally administered silybin, poor water-solubility can be the main restrictive physicochemical feature, which results in low oral bioavailability in the absorption. A milk thistle nanocrystal formulation (HM40) was prepared using a modif...

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Bibliografische gegevens
Hoofdauteurs: S M Seo, Gwanyoung Kim, Min Hwan Kim, Kyung Won Lee, Minjae Kim, Mansingh Chaudhary, Khadka Bikram, Taeheon Kim, Seungmok Choi, Hee‐Jin Yang, Joo Won Park, Dae‐Duk Kim, Ki-Taek Kim
Formaat: Artigo
Taal:Engels
Gepubliceerd in: 2024
Online toegang:https://doi.org/10.3390/pharmaceutics16081033
https://www.mdpi.com/1999-4923/16/8/1033/pdf?version=1722592580
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