DEPDC5 protects CD8+ T cells from ferroptosis by limiting mTORC1-mediated purine catabolism
Abstract Peripheral CD8 + T cell number is tightly controlled but the precise molecular mechanism regulating this process is still not fully understood. In this study, we found that epilepsy patients with loss of function mutation of DEPDC5 had reduced peripheral CD8 + T cells, and DEPDC5 expression...
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| Principais autores: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2024
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| Acesso em linha: | https://doi.org/10.1038/s41421-024-00682-z https://www.nature.com/articles/s41421-024-00682-z.pdf |
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