GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery

GATA6 identifies an immune-enriched phenotype linked to favorable outcomes in patients with pancreatic cancer undergoing upfront surgery

This study underscores GATA6's role in distinguishing classical and basal-like pancreatic ductal adenocarcinoma (PDAC) phenotypes. Retrospective studies associate GATA6 immunohistochemistry (IHC) expression with survival outcomes, warranting prospective validation. In a prospective treatment-na...

Бүрэн тодорхойлолт

-д хадгалсан:

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Casper W.F. van Eijck, Francisco X. Real, Núria Malats, Disha Vadgama, Thierry van den Bosch, Michail Doukas, Casper H.J. van Eijck, Dana A. M. Mustafa
Формат:	Artigo
Хэл сонгох:	англи
Хэвлэсэн:	2024
Онлайн хандалт:	https://doi.org/10.1016/j.xcrm.2024.101557 https://www.cell.com/article/S2666379124002490/pdf
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!

Ижил төстэй зүйлс

Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer
-н: Casper W.F. van Eijck, зэрэг
Хэвлэсэн: (2023)

Pancreatic Duct Obstruction in a Middle-Aged Woman: A Case Report
-н: Suker, Mustafa, зэрэг
Хэвлэсэн: (2017)

A Rare Tumor in the Common Bile Duct: A Case Report
-н: Suker, Mustafa, зэрэг
Хэвлэсэн: (2017)

Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer
-н: Eva Versteijne, зэрэг
Хэвлэсэн: (2018)

Circulating DNA and Micro-RNA in Patients with Pancreatic Cancer
-н: Vietsch, Eveline E, зэрэг
Хэвлэсэн: (2015)

Neoadjuvant therapy or upfront surgery for resectable and borderline resectable pancreatic cancer: A meta-analysis of randomised controlled trials
-н: Jacob L. van Dam, зэрэг
Хэвлэсэн: (2021)

Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib
-н: Julie Nonnekens, зэрэг
Хэвлэсэн: (2016)

Potentiation of Peptide Receptor Radionuclide Therapy by the PARP Inhibitor Olaparib
-н: Nonnekens, Julie, зэрэг
Хэвлэсэн: (2016)

Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma
-н: Elham Aïda Farshadi, зэрэг
Хэвлэсэн: (2021)

Oncolytic viruses: From bench to bedside with a focus on safety
-н: Pascal Buijs, зэрэг
Хэвлэсэн: (2015)

Oncolytic viruses: From bench to bedside with a focus on safety
-н: Buijs, Pascal RA, зэрэг
Хэвлэсэн: (2015)

Metformin boosts antitumor immunity and improves prognosis in upfront resected pancreatic cancer: an observational study
-н: Casper W.F. van Eijck, зэрэг
Хэвлэсэн: (2024)

Influence of type‐I Interferon receptor expression level on the response to type‐I Interferons in human pancreatic cancer cells
-н: Stephanie Booy, зэрэг
Хэвлэсэн: (2014)

Neoadjuvant Treatment in Patients With Resectable and Borderline Resectable Pancreatic Cancer
-н: Quisette P. Janssen, зэрэг
Хэвлэсэн: (2020)

Robust deep learning model for prognostic stratification of pancreatic ductal adenocarcinoma patients
-н: Ju, Jie, зэрэг
Хэвлэсэн: (2021)

Functional Changes after Pancreatoduodenectomy: Diagnosis and Treatment
-н: T.C.K. Tran, зэрэг
Хэвлэсэн: (2009)

Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
-н: Jeurnink, Suzanne M, зэрэг
Хэвлэсэн: (2007)

Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
-н: Suzanne M. Jeurnink, зэрэг
Хэвлэсэн: (2007)

IFN-β is a potent inhibitor of insulin and insulin like growth factor stimulated proliferation and migration in human pancreatic cancer cells
-н: Booy, Stephanie, зэрэг
Хэвлэсэн: (2015)

RNA from stabilized whole blood enables more comprehensive immune gene expression profiling compared to RNA from peripheral blood mononuclear cells
-н: van der Sijde, Fleur, зэрэг
Хэвлэсэн: (2020)

Reference values for white blood-cell-based inflammatory markers in the Rotterdam Study: a population-based prospective cohort study
-н: Jesse Fest, зэрэг
Хэвлэсэн: (2018)

Immune-Related Circulating miR-125b-5p and miR-99a-5p Reveal a High Recurrence Risk Group of Pancreatic Cancer Patients after Tumor Resection
-н: Vietsch, Eveline E., зэрэг
Хэвлэсэн: (2019)

Identification, Validation, and Utilization of Immune Cells in Pancreatic Ductal Adenocarcinoma Based on Marker Genes
-н: de Koning, Willem, зэрэг
Хэвлэсэн: (2021)

Reduction of Peritoneal Trauma By Using Nonsurgical Gauze Leads to Less Implantation Metastasis of Spilled Tumor Cells
-н: M. Petrousjka van den Tol, зэрэг
Хэвлэсэн: (1998)

Percutaneous Transhepatic Biliary Drainage in Patients with Postsurgical Bile Leakage and Nondilated Intrahepatic Bile Ducts
-н: E.A. de Jong, зэрэг
Хэвлэсэн: (2013)

Current evidence of nutritional therapy in pancreatoduodenectomy: Systematic review of randomized controlled trials
-н: Takagi, Kosei, зэрэг
Хэвлэсэн: (2019)

Dendritic Cell–Based Immunotherapy in Patients With Resected Pancreatic Cancer
-н: Freek R. van ‘t Land, зэрэг
Хэвлэсэн: (2024)

Study quality on groin injury management remains low: a systematic review on treatment of groin pain in athletes
-н: Andreas Serner, зэрэг
Хэвлэсэн: (2015)

The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey
-н: Edmée C.M. Sikkens, зэрэг
Хэвлэсэн: (2012)

Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors
-н: Floris Dammeijer, зэрэг
Хэвлэсэн: (2017)

Circulating Biomarkers for Prediction of Objective Response to Chemotherapy in Pancreatic Cancer Patients
-н: van der Sijde, Fleur, зэрэг
Хэвлэсэн: (2019)

Meta‐analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer
-н: Versteijne, E., зэрэг
Хэвлэсэн: (2018)

Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma
-н: Buijs, Pascal, зэрэг
Хэвлэсэн: (2015)

Patients with chronic mesenteric ischemia have an altered sublingual microcirculation
-н: Harki, Jihan, зэрэг
Хэвлэсэн: (2018)

FOLFIRINOX and radiotherapy for locally advanced pancreatic cancer: A cohort study
-н: Suker, Mustafa, зэрэг
Хэвлэсэн: (2018)

The Class I HDAC Inhibitor Valproic Acid Strongly Potentiates Gemcitabine Efficacy in Pancreatic Cancer by Immune System Activation
-н: Blaauboer, Amber, зэрэг
Хэвлэсэн: (2022)

The systemic immune‐inflammation index is associated with an increased risk of incident cancer—A population‐based cohort study
-н: Fest, Jesse, зэрэг
Хэвлэсэн: (2019)

Systematic review and meta-analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer
-н: Kirstin Marie Jeanne de Bruijn, зэрэг
Хэвлэсэн: (2013)

The systemic immune‐inflammation index is associated with an increased risk of incident cancer—A population‐based cohort study
-н: Jesse Fest, зэрэг
Хэвлэсэн: (2019)

The neutrophil-to-lymphocyte ratio is associated with mortality in the general population: The Rotterdam Study
-н: Jesse Fest, зэрэг
Хэвлэсэн: (2018)