The covariance environment defines cellular niches for spatial inference

A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the features of cellular neighborhoods or niches. Here we introduce the covariance environment (COVET), a representation that leverages the gene-gene covariate structure across cells in the...

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Autors principals: Doron Haviv, Ján Remšík, Mohamed I. Gatie, Catherine Snopkowski, Meril Takizawa, Nathan Pereira, John Bashkin, Stevan Jovanovich, Tal Nawy, Ronan Chaligné, Adrienne Boire, Anna‐Katerina Hadjantonakis, Dana Pe’er
Format: Artigo
Idioma:anglès
Publicat: 2024
Accés en línia:https://doi.org/10.1038/s41587-024-02193-4
https://www.nature.com/articles/s41587-024-02193-4.pdf
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