Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

RNase L is an endoribonuclease of higher vertebrates that functions in antiviral innate immunity. Interferons induce oligoadenylate synthetase enzymes that sense double-stranded RNA of viral origin leading to the synthesis of 2′,5′-oligoadenylate (2-5A) activators of RNase L. However, it is unknown...

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Hlavní autoři: Jiajia Xi, Goda Snieckute, José Francisco Martı́nez, Frederic Schrøder Arendrup, Abhishek Asthana, Christina Gaughan, Anders H. Lund, Simon Bekker‐Jensen, Robert H. Silverman
Médium: Artigo
Jazyk:angličtina
Vydáno: 2024
On-line přístup:https://doi.org/10.1016/j.celrep.2024.113998
https://www.cell.com/article/S2211124724003267/pdf
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https://doi.org/10.1016/j.celrep.2024.113998
https://www.cell.com/article/S2211124724003267/pdf

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